血浆氧化低密度脂蛋白、高敏C反应蛋白与脑梗死的相关性研究  

Correlation Between Blood Oxidized Low Density Lipoprotein and High-sensitivity C-Reactive Protein in Relation to Cerebral Infarction

作　　者：方晓霞[1,2] 周珂[1] 

机构地区：[1]武汉大学人民医院神经内科,湖北武汉430060 [2]郧阳医学院附属十堰市太和医院神经内科,湖北十堰442000

出　　处：《武汉大学学报（医学版）》2009年第2期238-241,共4页Medical Journal of Wuhan University

摘　　要：目的:研究血浆氧化低密度脂蛋白(OxLDL)、高敏C反应蛋白(hsCRP)与动脉粥样硬化血栓形成性脑梗死之间的关系。方法:选取75例经头颅MRI确诊的动脉粥样硬化性脑梗死住院患者,腔隙性脑梗死、心源性栓塞性脑梗死及病因不明性卒中均不在收集范围;同时选取同期体检年龄、性别一致的健康人群32例作为对照组。采用ELISA试剂盒检测血浆OxLDL水平,高敏C反应蛋白采用免疫比浊法检测,其他脑梗死危险因素如年龄、性别、血脂等数据也一并收集。由同一名神经科专业医师参照美国国立卫生院卒中量表对病例组进行神经功能缺损评定即NIHSS评分。结果:病例组血脂、血浆OxLDL水平以及血清hsCRP含量均显著高于对照组(P<0.05),且血浆OxLDL水平、血清hsCRP水平与NIHSS(national institutes of healthy stroke scale)评分呈正相关(r=0.685,r=0.673;P<0.05),而血脂水平与NIHSS评分则无相关关系。结论:血浆OxLDL水平、血清hsCRP与动脉粥样硬化血栓形成性脑梗死严重程度有一定关系。Objective： To explore the correlation among plasma oxidized low density lipoprotein （Ox- LDL）, high sensitivity C-reactive protein （hsCRP） and atherothrombotic infarction. Methods. Seventy-five patients with atherothrombotic infarction （AI） were involved in this study. Lacunar infarction, cardioembolic infarction and cryptogenic stroke patients were excluded. Thirty-two healthy subjects were selected as control. Plasma OxLDL level were detected with ELISA method. Serum hsCRP levels were detected with immunoturbidimetric assay. Other cerebral infarction related risk factors including age, sex, and serum lipids level were also examined. The degree of neurologic impairment in AI group was evaluated with National Institutes of Healthy Stroke Scale （NIHSS） by the same neurologist. Results： Both serum hsCPR and plasma OxLDL level in AI group were significantly higher than those in control group. Both plasma OxLDI. levels and serum hsCPR levels were significantly positively correlated with the NIHSS in AI group.Conclusion： The level of plasma OxLDL and serum hsCRP may have a relation to the severity of atherothrombotic infarction.

关 键 词：动脉粥样硬化 脑梗死 氧化低密度脂蛋白 高敏C反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]