湖州市女性HPV感染的分子流行病学分析  

A molecular epidemiologic study of human papillomavirus genotypes of women in Huzhou

作　　者：钱福初[1] 秦基取[1] 章彤华[1] 戴利成[1] 

机构地区：[1]浙江省湖州市中心医院,浙江湖州313000

出　　处：《中国卫生检验杂志》2009年第2期404-405,413,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的：调查湖州市女性人乳头瘤病毒（HPV）感染基因型的分子流行病学特点。方法：对450例湖州市女性宫颈分泌物应用基因芯片技术进行了18种高危型和5种低危型HPV型别检测，并结合年龄、文化程度等基本信息进行分析。结果：450例女性中共检出HPV阳性101例，占22．44％，其中单一感染80例，占17．78％；双重感染17例，占3．78％；三重及以上感染4例，占0．89％。101例阳性患者中有高危型HPV感染的为84例，占HPV总阳性人数的83．17％。阳性患者中高危型以16、33、58、18为主，低危型以6、11型为主。不同年龄组（≤30，31～40，41～50，〉50）的HPV感染率分别为27．38％、21．32％、18．81％、15．56％，随年龄增长有下降趋势，但经统计学检验差异无显著性（P〉0．05）。不同教育程度（小学及以下、初中、高中、大学及以上）的HPV感染率分别为23．08％、22．86％、21．74％、21．56％，也有随教育水平增高而下降的趋势，但经统计学检验差异无显著性（P〉0．05）。结论：湖州市女性HPV感染并不少见，且高危型HPV感染所占比例较高，在不同年龄和文化水平中差异无显著性。对适当年龄段女性进行HPV感染筛查和及早治疗，对宫颈癌的防治有重要意义。Objective：To understand the molecular epidemiologic character of 23 genotypes of human papillomavirus （HPV） infection of women in Huzhou. Methods： HPV genotypes of 450 women in Huzhou were examined by gene chip technique, then analysis the results combing the age and educational level. Results： Among the total 450 cases, 101 cases were HPV positive （22. 44 % ）, 80 cases （ 17. 78% ） were single HPV type infection and 17 cases （3.78%） were double HPV types infection and 4 cases （0. 89% ） were multiple HPV types infection respectively. In 101 HPV positive cases, the detecting total rates of high risk HPV genotypes were 83.17 % （84/101）. The major low risk HPV genotypes were 6,11 and most high risk HPV genotypes were 16,33,58,18. The rate of different age group （ ≤30,31 -40,41 -50, 〉50） were 27. 38% ,21.32% ,18.81% ,15.56% respectively and had no significant differences （ P 〉 0. 05 ）, The rate of different educational level group were 23.08%, 22. 86%, 21.74% ,21.56% respectively and had no significant differences（ P 〉 0. 05 ）. Conclusion： In the Huzhou City, HPV infection is quite a few in women. Furthermore, the infection of high risk genotypes occupy a big proportion. It is very important to detect HPV - DNA in appropriate age women and treat as early as possible for decreasing the risk of cervical cancer.

关 键 词：人乳头状瘤病毒 基因型 年龄 文化程度 

分 类 号：R737.33[医药卫生—肿瘤]