胶体磨制备冰片-β环糊精包合物工艺研究  

Reparation of Borneol-β-Cyclodextrin Inclusion Compound Process by Colloid Mill

作　　者：熊耀坤[1] 张国松[2] 魏惠珍[2] 李爽[1] 罗晓健[2] 

机构地区：[1]江西中医学院,南昌330004 [2]中药固体制剂制造技术国家工程研究中心,南昌330006

出　　处：《江西中医学院学报》2009年第1期30-33,共4页Journal of Jiangxi College of Traditional Chinese Medicine

基　　金：国家自然科学基金(30760313);江西省教育厅科技项目(GJJ08324)

摘　　要：目的:研究冰片β-环糊精胶体磨包合冰片的最佳工艺。方法:用正交试验设计法,以冰片包合率和包合物收得率为考察指标,研究物料比例、碾磨时间及加水量对使用胶体磨制备冰片β-环糊精包合物效果的影响。结果:优化工艺为:冰片与β-环糊精比例为1∶8,碾磨时间为45min,加水量为1倍。结论:经实验优选得到的工艺所得冰片包合率和包合物的收得率分别为95.2%和95.9%。objective ：To study the best technology of borneol-β-cyclodextrin inclusion compound process. Method：by the method of or- thogonal experiment, with the rate and yield of borneol-β-cyclodextrin as investigation index;to study and research the rate of materials, the time of grinding,the amount of imbitition which effect the result of borneol-β-Cyclodextrin inclusion compound process by colloid mill. Result：the optimize of technology：the rate of materials is 1：8 ;the time of grinding is 45 min;the amount of imbitition is 1. Conclusion：by optimizeing of technology, the rate and yield of Borneol-β-Cyclodextrin are 95.2% and 95.9%.

关 键 词：冰片 Β-环糊精 胶体磨 正交设计 

分 类 号：R282[医药卫生—中药学]