胰腺实性-假乳头状瘤临床病理特征及免疫表型观察  

Solid-pseudopapillary tumor of the pancreas:a study of clinicopathologic features and immunohistochemistry

作　　者：王翠芳[1] 孙洁[1] 滕猛[1] 

机构地区：[1]沈阳医学院奉天医院病理科,辽宁沈阳110024

出　　处：《沈阳医学院学报》2009年第1期34-36,45,共4页Journal of Shenyang Medical College

摘　　要：目的:探讨胰腺实性-假乳头状瘤(SPTP)免疫表型及临床病理特征。方法:对2例SPTP的临床表现、病理学改变、免疫组化等进行分析,并复习相关文献。结果:2例均为女性,且术后无复发。肿瘤有包膜,囊实性相间。瘤细胞围绕纤维血管排列形成假乳头状结构是特征性组织学改变。免疫组化2例肿瘤细胞均阳性的抗体有Vimentin、AAT、CD56、PCNA、MMP9、C-erbB2、Pgp。病例1部分细胞CK7、CD117、β-catenin阳性,病例2部分细胞Syn、CD10阳性。结论:SPTP是低度恶性肿瘤,多发生在年轻女性,可能来源于多能干细胞。虽然大部分肿瘤呈良性过程,但具有侵袭性行为。免疫组化检测对其组织来源及生物学行为具有提示意义,并可辅助诊断。Objective： TO explore the clinicopathologic features and the immunohistochemical expression in solid-pseudopapillary tumor of the pancreas （SPTP）. Methods： The clinical manifestations, pathological features and immunohistochemical resuhs in 2 cases of SPTP were analyzed by HE sections, PAS staining and immunohistochemistry （S-P method）. Results： 2 patients with SPTP were both females and had no recurrence after tumor resection. Both tumors were encapsulated and solid alternately with cystic change. Histological features were psudopapillary structure with a fibrovascular core Immunohistochemistry examination showed that Vimentin, AAT, CD56, PCNA, MMP9, C-erbB2, Pgp were all positive in two cases of SPTP. CK7, CD117, β-catenin, Syn, CD10 were positive in one case. Conclusion： SPTP is a tumor with low malignancy of the pancreas that most frequently affect young females. SPTP may derived from muhipotent stem cells. There is a benign clinical course in the most SPTP, but the tumor has a aggressive behavior. Immunohistochemical study could could sugsest, the origin and the biological behavior of SPTP. Immunohistochemistry is important to the diagnosis of SPTP.

关 键 词：胰腺实性-假乳头状瘤 临床病理特征 免疫组化 

分 类 号：R735.9[医药卫生—肿瘤]