改良兔体外循环模型的建立  

Establishment of rabbits model of cardiopulmonary bypass

作　　者：袁茂溪[1] 伍火志[1] 罗常进[1] 

机构地区：[1]遵义医学院第五附属珠海医院心胸外科,广东珠海519180

出　　处：《安徽医药》2009年第3期250-252,共3页Anhui Medical and Pharmaceutical Journal

基　　金：遵义医学院博士启动基金(No20040096)

摘　　要：目的建立改良的兔体外循环模型。方法采用股动脉插管,主动脉根部阻断右心房引流的方法建立兔体外循环,检测血流动力学指标的变化。结果18只兔成功建立体外循环模型,血流动力学指标在正常范围之内。停体外循环后心脏顺利复跳。结论通过本实验建立的兔体外循环模型,操作简单,更加符合临床研究体外循环的理想小动物模型。Aim To establish the rabbit model of cardiopulmonary bypass （CPB）. Methods CPB was established via a femoral artery catheterization, aortic root was blocked, right atrium was drained. Changes in hemodynamics were monitored. Results 18 rabbits were used successfully to establish model of cardiopulmonary bypass, hemodynamics were normal. After stopping CPB the heart successfully restored beating. Conclusion Through this experiment to establish the rabbit CPB model,we consider that the experimental procedure is simply,effectiveness and ideal small animal CPB model closed to clinical research.

关 键 词：体外循环 模型 兔 

分 类 号：R-332[医药卫生]