催化一锅法合成3，4-二氢嘧啶-2-酮  

Syntheses of 3,4-Dihydropyrimidine-2-(1H)-ones by One-pot Reaction

作　　者：康丽琴[1] 山炜巍[1] 魏邦国[2] 

机构地区：[1]上海应用技术学院化学工程系,上海200235 [2]复旦大学化学系,上海200243

出　　处：《化学通报》2009年第3期281-284,共4页Chemistry

摘　　要：以乙醇为溶剂,酸性离子液体为催化剂,通过三组分Biginelli反应3～5h,得到3,4-二氢嘧啶-2-酮类化合物。比较了几种常见离子液体对反应的影响,以[bmim][HSO4]对反应的催化活性最高,产率为78%～98%。产物后处理简单,催化剂可以回收利用,8次以后催化活性略有降低,是一种环境友好的绿色合成方法。3,4-Dihydropyrimidine-2-（ 1 H）-ones were synthesized by one-pot three-component Biginelli condensation in ethanol media under catalysis of acidic ionic liquids. It was found that the catalytic activity of [bmim] [ HSO4 ] is more effective among the used acidic ionic liquids. The reactions were completed during 3 - 5h with 78 - 98% yields. The products were convenient to work up. The catalysts could be recycled and reused eight times without noticeably decrease in the catalytic activity.

关 键 词：3 4-二氢嘧啶-2-酮 酸性离子液体 催化活性 

分 类 号：O626.41[理学—有机化学]