水蛭微粉对脑缺血再灌注损伤大鼠ICAM、VCAM、PDGF的影响  

Effect of Hirudo Micropowder on ICAM,VCAM and PDGF in Rats with Cerebral Ischemia-Reperfusion Injury

作　　者：李克明[1] 武继彪[2] 隋在云[1] 王爱洁[1] 

机构地区：[1]山东省中医药研究院,济南250014 [2]山东中医药高等专科学校,山东莱阳265200

出　　处：《中药新药与临床药理》2009年第2期136-138,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家中医药管理局资助课题(04-05ZP41)

摘　　要：目的研究水蛭微粉对脑缺血再灌注损伤大鼠炎症因子的影响。方法将大鼠随机分为假手术组、模型组、水蛭粗粉组及水蛭微粉高、中、低剂量组。灌胃给药10d后,用线栓法制备大脑中动脉闭塞模型,观察大鼠的炎症因子变化。结果水蛭微粉高剂量组细胞间黏附分子1(ICAM-1)显著低于粗粉组;水蛭微粉中、高剂量组血小板源生长因子(PDGF)显著低于粗粉组(P<0.01)。结论水蛭微粉可以减少炎症因子的产生,减轻炎症反应,明显改善大鼠脑缺血再灌注损伤,而且作用效果明显优于粗粉。Objective To investigate the effect of hirudo micropowder on inflammatory factors in rats with cerebral ischemia - reperfusion injury. Methods Rats were randomly divided into sham - operation group, model group, coarse powder hirudo group, high - , middle - and low - dose micropowder hirudo groups. The corresponding drugs were given to the rats for 10 days by intragastric administration. Then middle cerebral artery occlusion （MCAO） model was made by suture method. The changes of inflammatory factors were observed. Results The level of intercellular adhesion molecule 1 （[CAM - 1） in high - dose micropowder hirudo group was lower than that in coarse powder hirudo group, and the level of platelet - derived growth fac- tor （PDGF） in middle - and high - dose micropowder hirudo groups was also lower than that in coarse powder hirudo group obvi- ously （ P 〈 0. O1 ）. Conclusion Hirudo micropowder could improve cerebral ischemia - reperfusion injury in rats through reducing the production of inflammatory factors and the inflammatory reaction, and its effect is stronger than hirudo coarse powder.

关 键 词：水蛭 超微粉碎 脑缺血 再灌注损伤 大鼠 

分 类 号：R285.5[医药卫生—中药学]