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作 者:陈明净[1] 翁阳[2] 罗志飞[2] 杨丞[2] 丁莉利[2] 李学农[1]
机构地区:[1]南方医科大学病理学教研室,广东广州510515 [2]海南医学院病理学教研室,海南海口571101
出 处:《中国热带医学》2009年第4期648-650,共3页China Tropical Medicine
基 金:海南省自然科学基金项目(No.30521)
摘 要:目的探讨β-连接素(β-catenin,β-cat)在胃癌原发灶及相应淋巴结转移癌中的表达及意义。方法采用免疫组织化学(S-P)法检测28例远癌正常胃组织,70例胃癌(48例有淋巴结转移)及相应淋巴结转移癌中β-cat的表达。结果70例胃癌组织中β-cat表达率为68.6%,远低于正常胃组织的阳性率(92.9%)(P<0.05)。β-catenin在48例胃癌原发灶和淋巴结转移癌中的表达率有较高的一致性(两者均表达占41.1%,两者均不表达占25%)。β-cat的阳性表达与胃癌的分化程度、浸润深度及淋巴结转移密切相关(P<0.05),且在胃癌原发灶与其淋巴结转移癌中显著相关(列联系数R=0.317,P<0.05)。结论β-cat可作为判断胃癌生物学行为的指标,为预测胃癌的转移及预后评估提供依据。Objective To investigate the expression and significance of β-catenin in gastric carcinoma and their lymph node metastatic tumors. Methods Iminunohistoehemical staining method was used to detect the expression of β-catenin in 28 cases of normal gastric tissue, 70 eases of gastric carcinoma (48 cases with lymphatic metastasis) and their lymph node metastatic tumors. Results The study showed that β-catenin was expressed in gastric cancer tissues and lymph node metastatic tumors with positive rate of 68.6% and 56.3%, respectively, which indicated β-catenin expression was associated with tumor differentiation, invasion and lymph node metastasis (P〈0.05). Furthermore, the positive expression of β-catenin in metastatic gastric carcinoma was significantly correlated with primary lesions and lymph nodes metastasis (r=0.317 ,P〈0.05). Conclusion The expression of β-catenin was an index of biological behaviour of gastric carcinoma, which are important factors for judging invasion, metastasis and differentiation.
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