急性重复缺氧与动物脑组织细胞保护作用的研究  

Protecting effect of animal brain with acute and repetitive hypoxia

作　　者：潘颖[1] 杨典洱[1] 于培兰[1] 

机构地区：[1]首都医科大学生物化学教研室

出　　处：《中国病理生理杂志》1998年第1期47-49,共3页Chinese Journal of Pathophysiology

摘　　要：目的：观察急性重复缺氧动物产生间歇性低氧适应及对脑组织细胞的保护作用。结果：一次急性缺氧时血液和脑组织中的ＧＳＨｐｘ活性明显下降（Ｐ＜００１），其中脑组织中的ＧＳＨｐｘ活性在急性重复缺氧时被激活（Ｐ＜００５）。脑组织抗氧化能力增强。同时脑组织的Ｇｌｓ含量明显下降（Ｐ＜００１）。结论：Ｇｌｓ和ＧＳＨｐｘ有抗自由基活性。急性重复性缺氧Ｇｌｓ下降同时ＮＥ下降，不同于持续性低氧表现，推测脑细胞β受体－腺苷酸环化酶系统在急性重复缺氧时未受严重伤害。AIM:To study intermittent hypoxia adaptation can be produced by acute and repetitive hypoxia,and protecting effect animal brain cells with ischemia.RESULTS:The activity of GSHpx was decreased( P <0.01),not only in blood but also in brain. When repetitive hypoxia for 4 times, the activity of GSHpx in brain was increased again( P <0.01).At the same time,the gangliosides in the membrane of brain cell were decreased ( P <0 01).It showed that Gls and the activity of GSHpx were interrelated.The contents of norepinephrine in brain were lower than the controls ( P <0 01).CONCLUSION:β receptor-adenylcyclase system was not injured by acute and repetitive hypoxia..

关 键 词：缺氧症 小鼠 脑缺血 脑组织细胞 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学]