肝脏注射促肝细胞生长素和地塞米松对肝硬化肝窦病变及Ⅳ型胶原表达的影响  

Effects of intrahepatic injection with hepatocyte growth factor and dexamethason on stereological quantitative changes of hepatic sinusoidal disease and expression of Ⅳ-collagen on hepatic sinusoidal walls

作　　者：丁体龙[1] 马勇 袁福华 严家春 

机构地区：[1]蚌埠医学院医学检验系硕士研究生,安徽省蚌埠233030 [2]解放军第一二三医院肝病中心

出　　处：《中国基层医药》2009年第2期207-208,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察肝脏注射促肝细胞生长素和地塞米松对肝硬化肝窦组织病变的体视学改变及肝窦Ⅳ型胶原表达的影响。方法在超声引导下，对98例肝硬化患者肝脏注射促肝细胞生长素80mg及地塞米松1mg，每周注射2次，12次为一疗程，治疗1个疗程后，通过肝脏穿刺活检病理观察肝窦组织病变变化情况及Ⅳ型胶原的表达情况。结果98例肝硬化患者治疗1个疗程后，肝窦组织病变明显改善（P〈0．01），Ⅳ型胶原表达显著减弱（P〈0．01）。结论对肝硬化患者行超声引导下肝脏注射促肝细胞生长素和地塞米松能明显改善肝窦组织病变及Ⅳ型胶原的表达。Objective To observe the effects of intrahepatic injection with hepatocyte growth factor and dexamethason on stereological quantitative changes of hepatic sinusoidal tissues and expression of Ⅳ-collagen on hepatic sinusoidal walls of patients with hepatic cirrhosis. Methods Under the guide of hypersound,98 cases of hepatic cirrhosis were intrahepatic injected with 80mg hepatocyte growth factor and 1 mg dexamethason at one time, twice a week, 12 times a course, pathological changes of hepatic sinusoidal tissues and the expression of Ⅳ-collagen on hepatic sinu- soidal wails were detected by liver biopsy after one course. Results Pathological changes of hepatic sinusoidal tissues were improved obviously（ P 〈 0. 01 ） and the expression of Ⅳ-collagen was alleviated significantly（ P 〈 0. 01 ） on 98cases of hepatic cirrhosis after one course. Conclusion Pathological changes of hepatic sinusoidal tissues and the expression of Ⅳ-collagen on hepatic sinusoidal walls can be improved obviously on patients with hepatic cirrhosis who had been intrahepatic injected with hepatocyte growth factor and dexamethason under the guide of hypersound.

关 键 词：体视学分析 胶原Ⅳ型 肝硬化 肝细胞生长因子 地塞米松 

分 类 号：R575[医药卫生—消化系统]