铂类耐药性卵巢上皮癌患者卵巢上皮中VEGF-C表达的研究  

Expression of VEGF-C protein in platinum-resistant epithelial ovarian cancer

作　　者：王婧[1] 马晓艳[1] 李海霞[2] 

机构地区：[1]吉林大学第二医院妇产科,吉林长春130041 [2]吉林省妇幼保健院

出　　处：《中国妇幼保健》2009年第7期969-970,共2页Maternal and Child Health Care of China

基　　金：吉林省科技厅资助项目〔20030538-4〕

摘　　要：目的:探讨铂类耐药性卵巢上皮癌患者卵巢上皮癌组织中VEGF-C蛋白的表达。方法:应用免疫组织化学染色法检测43例卵巢上皮癌组织中VEGF-C蛋白的表达,同时检测其在中-高分化的卵巢癌组织中的单层、复层及癌巢的表达情况。结果:VEGF-C蛋白在中-高分化的卵巢癌组织中的单层、复层及癌巢的表达无显著性差异(P>0.05)。在耐药复发组和为复发组的癌组织中VEGF-C蛋白表达有显著性差异(P<0.05)。耐药复发组中单层上皮、癌巢中存在VEGF-C过表达。结论:VEGF-C蛋白在卵巢癌组织中的表达与组织学分级不具有明显相关性。VEGF-C蛋白在耐药组卵巢组织存在过表达,VEGF-C蛋白的检测对提示可能出现铂类耐药有重要价值。Objective： To explore the expression of vascular endothelial growth factor - C （ VEGF - C ） in platinum - resistant epithelial ovarian cancer. Methods： Surgical specimens from 43 patients with platinum - resistant epithelial ovarian cancer were examined for expression of VEGF - C protein by immunohistochemical staining. The expression of VEGF - C in single epithelium, stratified epithelium and the cancer cell group were detected. Results： There was no significant difference in the expression of VEGF - C between single epithelium, stratified epithelium and the cancer cell group in middle - high histological differentiation ovarian cancers （ P 〉0. 05 ） . There was significant difference in the expression of VEGF - C between platinum - resistant cancer and none platinum - resistant cancer （ P 〈 0. 05 ） . VEGF - C over- expression was found in single epithelium and the cancer cell group of platinum - resistant epithelial ovarian cancer patients. Conclusion： The expression of VEGF - C and the histological grade does not have obvious relevance. VEGF - C overexpression is found in platinum - resistant cancer tissue. VEGF - C may be a valuable facor to predict platinum resistance.

关 键 词：血管内皮生长因子C 卵巢肿瘤 免疫组化 耐药 

分 类 号：R737.31[医药卫生—肿瘤]