血清CA125在妇科疾病诊断中的临床意义  

Clinical significance of serum CA125 in the diagnosis of gynecological diseases

作　　者：王影[1] 张晓霞[1] 费军伟[1] 刘艳丰[1] 王毅[1] 

机构地区：[1]吉林大学第一医院妇产科,吉林长春130021

出　　处：《中国妇幼保健》2009年第9期1188-1190,共3页Maternal and Child Health Care of China

摘　　要：目的:检测妇科住院患者血清癌抗原125(Cancer antigen 125,CA125)水平,探讨血清CA125在妇科疾病诊断中的临床意义。方法:采用电化学发光法测定232例妇科住院手术患者血清CA125水平,以门诊体检健康妇女15例作对照,分组分析血清CA125水平。结果:23.3%卵巢癌患者血清CA125在400～1000U/ml之间,55.8%血清CA125大于1000U/ml,51.7%卵巢子宫内膜异位囊肿、68.8%子宫腺肌病及54.5%输卵管卵巢脓肿患者血清CA125在35～199U/ml之间;卵巢癌患者血清CA125显著增高,阳性率为97.7%,与妇科其他良、恶性肿瘤比较差异有显著性(P<0.01);卵巢子宫内膜异位囊肿、子宫腺肌病、输卵管卵巢脓肿患者血清CA125阳性率分别为62.1%、68.8%及81.8%,显著高于正常对照组(P<0.01),但显著低于卵巢癌组(P<0.05)。结论:血清CA125在卵巢癌诊断中有重要意义;对卵巢子宫内膜异位囊肿、子宫腺肌病及输卵管卵巢脓肿有一定诊断意义。Objective： To detect the level of serum cancer antigen 125 （ CA125 ）, explore the clinical significance of serum CA125 in the diagnosis of gynecological diseases. Methods： The level of serum CA125 was detected by electrochemiluminescence immunoassay （ECLIA） in 232 women undergoing gynecological operation and 15 healthy women. Results： The percentage of the level of CA125 between 400 U/ml and 1000 U/ml was 23.3% in women with ovarian cancer, while the percentage of the level of CA125 over 1000 U/ml was 55.8%. The percentages of the level of CA125 between 35U/ml and 199 U/ml were 51.7% in women with endometriotic cysts of the ovary, 54. 5% in women with adenomyosis and 68. 8% in women with tube - ovarian abscess, respectivly; the positive rate of CA125 in women with ovarian cancer was 97.7%, which was significantly higher than those with the other benign and malignant tumors （ P 〈0.01 ） ; the positive rates of CA125 in women with endometriosis, adenmyosis and tube -ovarian abscess were 62. 1% , 68.8% and 81.8% , respectivly, which were significantly higher than control group （ P 〈 O. O1 ）, but were lower than ovarian cancer group （ P 〈 0.05 ） . Conclusion： CA125 plays an important role in the diagnosis of ovarian cancer, which is a useful diagnostic method for endometriosis, adenmyosis and tubo-ovarian abscess.

关 键 词：癌抗原125 卵巢癌 卵巢子宫内膜异位囊肿 子宫腺肌病 输卵管卵巢脓肿 

分 类 号：R737.31[医药卫生—肿瘤]