非甲—戊型肝炎中自身免疫性肝病的临床研究  

Study on non-A to E hepatitis in autoimmune liver disease

作　　者：孙燕燕[1] 刘娅[2] 王煜[2] 张爱芸[2] 赵旭[1] 

机构地区：[1]宁夏医科大学研究生处,宁夏银川750004 [2]宁夏医科大学附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2009年第3期225-226,共2页Ningxia Medical Journal

摘　　要：目的通过对非甲-戊型肝炎中自身抗体的检测和临床特征的研究,提高对自身免疫性肝病的认识。方法对住院的143例非甲-戊型肝炎患者的临床及实验室检查资料进行回顾性分析。结果确诊的31例自身免疫性肝病患者,自身抗体以抗核抗体(ANA)、抗平滑肌抗体(SMA)、抗线粒体抗体(AMA)为主;除原发性硬化性胆管炎(PSC)外,大多为中年女性,多表现黄疸、乏力、食欲不振、腹胀、肝脾肿大,谷丙转氨酶和谷草转氨酶、免疫球蛋白明显升高。其他病因不明的非甲到戊肝炎患者以中青年男性、急性黄疸多见,肝功能受损轻。结论自身免疫性肝病具有高滴度自身抗体、肝功能等生化指标明显异常。Objective To study the clinical characteristics of non -A to E hepatitis by detecting autoantibodies and to under- stand autoimmune liver disease. Methods The clinical and laboratory data of 143 patients with non - A to E hepatitis were retrospectively analyzed in our hospital from January 2005 to March 2008. Results 31 cases were diagnosed as autoimmune liver disease patients, and the mainly antibodies were anti - nuclear antibody （ANA） , anti - smooth muscle antibodies （SMA） and anti - mitochondrial antibodies （AMA）. Most cases were middle - aged women, and the present symptoms were jaundice, fatigue, and loss of appetite, abdominal distention, and hepatosplenomegaly, with higher arninotransferase and obviously abnormal IgG and IgM. Other unknown causes of patients with non - A to E hepatitis was mainly young and middle - aged male patients and most of them were diagnosed as acute icter- ic hepatitis, with lighter impairing liver function. Conclusion The characteristics of autoimmune liver disease are with high titer autoantibody and obviously abnormal biochemical indicators of liver function.

关 键 词：非甲-戊型肝炎 自身免疫性肝病 自身抗体 

分 类 号：R575[医药卫生—消化系统]