骨桥蛋白、核因子-κB p65在非小细胞肺癌中的表达  

Expression of osteopontin and NF-кB p65 in non-small cell lung cancer

作　　者：路会玲[1] 王翎[1] 

机构地区：[1]苏州大学附属第一医院特需病区,215006

出　　处：《江苏医药》2009年第3期254-256,I0004,共4页Jiangsu Medical Journal

基　　金：江苏省社会发展科技项目(BS2005619)

摘　　要：目的探讨骨桥蛋白(OPN)和核因子-κBp65(NF-κBp65)在非小细胞肺癌(NSCLC)中的表达及两者与临床病理特征的关系。方法采用免疫组化检测80例NSCLC和21例正常肺组织中OPN和NF-κBp65的表达,并分析OPN和NF-κBp65的表达与NSCLC临床病理特征及患者生存时间之间的关系。结果OPN和NF-κBp65在NSCLC中表达阳性率分别为63.75%、61.25%,在正常肺组织中表达阳性率分别为23.81%、9.52%。NSCLC中OPN和NF-κBp65表达显著高于正常组织(P<0.05)。OPN和NF-κBp65的表达率与患者的淋巴结转移、TNM分期有密切关系;OPN表达还与患者组织学类型有关(P<0.05)。OPN和NF-κBp65为负性预后因子;OPN和NF-κBp65之间呈正相关。结论OPN和NF-κBp65在肺癌中高表达,OPN和NF-κBp65阳性表达提示预后不良。Objective To explore the relationship between the expressions of osteopontin （OPN） and nuclear factor-κB p65（NF-κB p65） and the clinicopathologie characteristics of non-small cell lung cancer（NSCLC）. Methods Immunohistoehemistry was used to detect the expressions of OPN and NF-κB in NSCLC of 80 cases and normal lung tissues of 21 cases. Survival analysis was performed statistically to reaveal the relationship between the expressions of OPN and NF-κB p65 and the clinicopathologic characteristics and servival time of NSCLC. Results The positive expression rates of OPN and NF-κB were 63.75M and 61.25%, respectively, in 80 patients with NSCLC, and 23.81% and 9.52% ,respectively,in 21 normal lung tissues. The expressions of OPN and NF-κB p65 were significantly correlated with lymph node metastasis and clinical stages. OPN was correlated with histological classification. OPN and NF-κB p65 would be the negative prognostic factors. There were positive correlations between OPN and NF-κBp65. Conclusion Overexpressions of OPN and NF-κB p65 is presented in NSCLC, which predicates a poor prognosis.

关 键 词：骨桥蛋白 核因子-ΚB P65 非小细胞肺癌 

分 类 号：R734[医药卫生—肿瘤]