天津大港油田肺癌病例对照研究  

A Case Control Study of Lung Cancer Among Workers in Dagang Oil Field,Tianjin,China

作　　者：范亚光 魏健[3] 白云[1] 徐立滨[3] 姜勇[4] 赵永成[2] 乔友林[4] 周清华[1] 

机构地区：[1]天津医科大学总医院天津市肺癌研究所,天津300052 [2]中国医学科学院放射医学研究所,天津300192 [3]大港油田总医院,天津300280 [4]中国医学科学院肿瘤研究所,北京100021

出　　处：《中国肺癌杂志》2009年第1期64-67,共4页Chinese Journal of Lung Cancer

基　　金：国家“十一五”科技支撑计划课题(No.2006BAI02A01)资助~~

摘　　要：背景与目的研究中国天津大港油田职工肺癌的危险因素。方法采用病例对照研究对有关的暴露因素进行单因素和多因素Logistic回归分析。结果单因素和多因素分析结果均表明,吸烟和既往肺部疾病可增加大港油田职工肺癌的发病危险,调整的OR及95%可信区间(Confidence interval,CI)分别为1.52(1.18-1.94)和3.37(1.88-7.16),化学有害物质和粉尘暴露的OR及其95%CI分别为0.73(0.69-1.30)和0.84(0.62-1.15),未见癌家族史与肺癌有显著性关联。结论吸烟和既往肺部疾病为大港油田肺癌独立危险因素,职业暴露与肺癌的关系由于受潜在偏倚的影响,尚需进一步深入研究。Background and objective To investigate the risk factors of lung cancer among the employees who had worked in Dagang oil field, Tianjin, China. Methods A matched ease control study was conducted to analyse the association between some exposures and lung cancer risk by univariate and multiple Logistic regression method. Results According to the results from univariate and multiple analysis, smoking and previous lung disease increase lung cancer risk with adjusted OR of 1.52 （95%Ch 1.18-1.94） and 3.37 （95%Ch 1.88-7.16） respectively, while the adjusted OR for occupational chemical toxic substance and dust exposure is 0.73 （95%Ch 0.69-1.30） and 0.84 （95%Ch 0.62-1.15） respectively, and there is no significant association between family history of cancer and lung cancer risk in this study. Conclusion Smoking and previous lung disease are the independent risk factors for lung cancer among workers in Dagang oil field, yet due to some potential epidemiological bias, the association between occupational exposure and lung cancer needs further investigation.

关 键 词：肺肿瘤 病例对照研究 吸烟 既往肺部疾病 职业暴露 

分 类 号：R734.2[医药卫生—肿瘤]