川芎嗪对轻度烧伤大鼠烧伤痛行为学影响研究  

Effect of TMP on Burn Pain Behavior in Mild Burn Injury Rats

作　　者：高云[1] 梁尚栋[1] 穆松牛[2] 刘征宇[3] 姜建梅[3] 徐昌水[1] 李桂林[1] 康路妹[2] 刘晗[1] 

机构地区：[1]南昌大学基础医学院生理教研室,南昌330006 [2]南昌大学实验动物科学部,南昌330006 [3]南昌大学实验教学部,南昌330006

出　　处：《江西医学院学报》2009年第1期1-3,12,共4页Acta Academiae Medicinae Jiangxi

基　　金：国家自然科学基金(30860333);江西省自然科学基金(2007GZY1002)

摘　　要：目的探讨川芎嗪对轻度烧伤大鼠痛行为的影响,了解川芎嗪对烧伤痛的作用。方法建立大鼠轻度烧伤模型,应用von Frey细丝法和热辐射法测定机械缩足反射阈值(mechanical withdrawal threshold,MWT)和热缩足反射潜伏期(thermal withdrawal latency,TWL),观察川芎嗪对烧伤大鼠MWT和TWL的影响。结果烧伤后1h,ⅢA组(生理盐水+Ⅰ度烧伤组)和ⅢB组(生理盐水+浅Ⅱ度烧伤组)MWT和TWL显著性下降,分别持续24h和96 h(P<0.01)。24 h之后,ⅡA组(TMP+Ⅰ度烧伤组)TWL和TWL和Ⅰ组相比无显著性差异,而ⅡB组(TMP+浅Ⅱ度烧伤组)24 h后明显增加,72 h后与Ⅰ组相比已没有显著性差异。结论川芎嗪可以抑制烧伤大鼠的机械缩足反射阈值和热缩足反射潜伏期,从而对烧伤痛有抑制作用。Objective To investigate the effects of tetramethylpyrazine （TMP） on burn pain behavior in mild burn injury rats,and find out how TMP effects the burn pain. Methods First degree and superfacial second degree burn injury model was adopted. Mechanical withdrawal threshold and thermal withdrawal latency were measured. Results Mild burn pain model was adopted. At hour 1 after operation, the mechanical withdrawal threshold and thermal withdrawal latency in group ⅢA （First degree burn ＋NS group） and group ⅢB （superfacial second burn ＋ NS group） were lower than group Ⅰ （sham）, lasting for 24 or 96 hours respectively （P〈0.01） . After 24 hour, MWL and TWL of group ⅢA increased and had no difference from group Ⅰ , and group ⅢB had no difference from group Ⅰ after 72 hour. Conclusion TMP could decrease MWT and TWL of mild burn injury rats, and may alleviate burn pain induced.

关 键 词：川芎嗪 烧伤痛 动物 实验 大鼠 

分 类 号：R-332[医药卫生]