霍奇金淋巴瘤细胞转染mtrⅡ基因后CD30表达的意义  

Expression of CD30 in Hodgkin lymphoma cells transfected with mtr Ⅱ gene

作　　者：林雨冬[1] 蔡绍环[1] 王明元[1] 陈聪[1] 杜京丽[1] 

机构地区：[1]南京军区福州总医院九五临床部,福建莆田351100

出　　处：《白血病．淋巴瘤》2009年第3期129-130,133,共3页Journal of Leukemia & Lymphoma

基　　金：基金项目：福建省自然科学基金（C0410048）

摘　　要：目的探讨CD30在转染mtrⅡ基因后的霍奇金淋巴瘤（HL）细胞中的表达情况及其意义。方法将mtrⅡ转染人类HL细胞株，采用免疫组织化学方法检测转染前后CD30的表达情况。结果未转染mtrⅡ基因霍奇金淋巴瘤细胞中的CD30阳性率为（1．2％），转染mtrⅡ基因后阳性率为（26．8％），二者之间差异有统计学意义（P〈0．01）。结论mtrⅡ基因可能参与了HL细胞恶性转化的过程。Objective To approach the expression and significance of CD30 in Hodgkin lymphoma cells which were transfected with mtr Ⅱ gene. Methods The CD30 expression of Hodgkin lymphoma cells in those transfected with mtr Ⅱ gene was analysed by immunohistochemical technique respectively. Results The CD30 expression rate of Hodgkin lymphoma cells which were transfected with mtr Ⅱ gene was higher than that of Hodgkin lymphoma cells which weren＇ t transfected with mtr Ⅱ gene （P 〈0.01）. Conclusion The mtr Ⅱ gene may be related to the malignant transformation of Hodgkin lymphoma.

关 键 词：mtrⅡ基因 霍奇金淋巴瘤 抗原  CD30 

分 类 号：R733.1[医药卫生—肿瘤] R739.63[医药卫生—临床医学]