G蛋白偶联受体120研究进展  

Progress of Research about G Protein-Coupled Receptor 120

作　　者：孙超[1] 张忠品[1] 

机构地区：[1]西北农林科技大学动物科技学院,陕西杨凌712100

出　　处：《家畜生态学报》2009年第1期91-94,共4页Journal of Domestic Animal Ecology

基　　金：国家自然科学基金项目(30871785);教育部重点项目(105167);教育部新世纪优秀人才计划项目(NCET-06-0865);国家"十一五"科技支撑计划项目(2006BAD04A11)

摘　　要：游离脂肪酸(FFAs)是一种重要能量来源并起到信号分子的作用,外周游离脂肪酸水平升高与糖尿病、肥胖以及脂代谢紊乱紧密相关。G蛋白偶联受体(G protein-coupled re-ceptors,GPCR)是一种含有7个α螺旋的整合膜蛋白,是细胞表面最大的受体超家族。GPR120是一种新发现的游离脂肪酸受体,它直接或者间接参与调节体内一系列代谢过程,如激素分泌、葡萄糖代谢、脂质生成、信号转导等。作为一潜在的治疗多种代谢疾病的药物靶标,GPR120的生理功能及作用的分子机制等都值得进一步研究。Free Fat Acids（FFAs）provide an important energy source and also act as signaling molecules. The increase of peripheric FFAs level is close related to diabetes, obesity and lipid metabolism disorder. G protein-coupled receptors （GPCR） are integral membrane proteins with seven α-helices, and are the largest receptor super-family located at the cell surface. GPR120, a novel FFA receptor, can directly or indirectly regulate a series of in vivo metabolic processes, such as hormone secretion, glucose metabolism, signal transduction. As a potential therapeutic target for different metabolic diseases, the physiological function of GPR120 and its biological mechanism deserve further investigation.

关 键 词：GPCRS FFAS GPR120 糖尿病 肥胖症 

分 类 号：S811.5[农业科学—畜牧学]