TOPO-2在乳腺癌表达中的表达及相关意义  

Relationship and significance of expression of topoisomerase Ⅱ(TOPⅡ) in the human breast carcinoma tissue

作　　者：王承正[1] 毛书明[1] 崔树德[1] 

机构地区：[1]河南省肿瘤医院乳腺科,郑州450003

出　　处：《医学信息（手术学分册）》2008年第12期1059-1061,共3页Medical Information Operations Sciences Fascicule

摘　　要：目的探讨拓扑异构酶Ⅱ在乳腺癌组织中的表达规律及在乳腺癌治疗中的预测价值。方法应用SP免疫组织化学方法,检测资料完整的100例浸润性乳腺癌组织标本。结果拓扑异构酶Ⅱ在100例浸润乳腺癌组织中表达的阳性率为48.0%,其与乳腺癌淋巴结转移?HER-2蛋白表达密切相关(P<0.05),而与患者年龄?月经情况、肿瘤大小、临床分期、组织学分级、ER状态无相关(P>0.05)。结论拓扑异构酶Ⅱ在乳腺癌组织中的高表达与乳腺癌的发生发展转移密切相关,其在乳腺癌的治疗和预后中可能起重要作用。Objective To explore the regularity of expression of TOP Ⅱ in the breast cancer and its prognostic valument in the treatment of the breast cancer. Methods The expression of TOP Ⅱ was measured by immmunohisto- chemical assay in 100 eases of infiltrative type of breast carcinoma tissue all which have complete dates. Results The positive expression rates of TOP Ⅱ was 48.0% in the breast carcinoma , overexpression of TOP Ⅱ was significantly cor- related with axillary lymphonodus metastasis, expression of HER - 2 （ P 〈 0.05 ）, but it was insignificantly correlated with ages, menstruatiion, clinical TNM stage, tumor size, histologic grade, ER （ P 〉 0.05 ）. Conclusions The overex- pression of TOP Ⅱ was closed correlated with the development and metastasis of breast carcinoma , TOP Ⅱ may play a certain role in evalution prognosis and clinical treatment.

关 键 词：拓扑异构酶 乳腺癌 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]