危重患者预警蛋白质组指纹表达与促甲状腺素、游离三碘甲状腺原氨酸、游离甲状腺素的相关性研究  

Study on the expression of LGT proteinic fingerprint in the change of TSH, FT3, FT4

作　　者：裴毅[1] 魏淑青[1] 杨永明[1] 任晓辉[2] 黄金[2] 

机构地区：[1]山西省肿瘤医院老年病科,太原030013 [2]山西医科大学研究生处

出　　处：《肿瘤研究与临床》2009年第3期183-184,187,共3页Cancer Research and Clinic

摘　　要：目的探索癌症患者病情危重至死亡发生前促甲状腺素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）的变化情况。方法能接受抗肿瘤治疗且不伴有甲状腺疾病的晚期癌症患者84例，年龄24～85岁，男56例，女28例，行表面增强激光解析／电离飞行时间质谱蛋白芯片技术（SELDI技术）检查，以质荷比（M／Z）为11100＋H～11900＋H有无峰簇，分成危重患者预警蛋白（LGT）阳性组和阴性组。所有患者行TSH、FT3、FT4检查，对结果行统计学分析。结果LGT阳性组TSH、FT3、FT4值显著低于LGT阴性组。在LGT阳性组中，TSH、FT3、FF4之间无相关性；LGT阴性组中，FT3与FT4之间呈正相关，而与TSH无相关性。结论肿瘤患者病情稳定阶段机体的甲状腺功能基本是正常的，当处于疾病末期及死亡发生前期，有可能出现垂体一甲状腺功能低下，这有可能是加速患者死亡的一个重要因素，但这个现象的出现与LGT高表达之间的因果关系尚不明确。在患者病情危重时检查甲状腺功能，并根据结果补充适量的甲状腺激素是有益的。Objective Exploration of TSH, FT3, FT4 changes in critical condition prior to death. Methods 84 patients that were anti-tumor therapy acceptable and not associated with the treatment of thyroid disease in patients with terminal tumors. Age from 24 to 85-year-old, male 56, female 28. The use of SELDI technology （surface-enhanced laser description / ionization time-of-flight mass spectrometry protein chip technology） checks to M/Z for the 11 100 ＋ H-11 900 ＋ H peak of the cluster, divided into the positive group for critically ill patients with early warning protein （LGT） and the negative group for it. All patients were given TSH, FT3, FT4 inspection. The results were statistically analyzed. Results TSH, FT3, FT4 in the LGT positive group was significantly lower than in the negative LGT group. There was no correlation between TSH, FT3 and FT4 in the LGT positive group;In the negative LGT group FT3 and FF4 had a positive correlation, and FF3 and TSH no relevance. Conclusion Thyroid function is normal in the stage of cancer patients stable condition. Possible pituitary-hypothyroidism may occur as the disease advances to the end or before death. This may be an important factor causing the acceleration to the death of the patients. However, the cause and effect between this phenomenon and the early warning of protein fingerprint group（LGT） is still not clear. In critical condition checking thyroid function and render supplementary amount of thyroid hormone in accordance with the checking results may be beneficial.

关 键 词：肿瘤 促甲状腺素 三碘甲状腺原氨酸 甲状腺素 蛋白质组 

分 类 号：R730[医药卫生—肿瘤]