p21^cip1在肿瘤生物治疗中的地位与作用  

Status and role of p21^cip1 for cancer biological therapy

作　　者：陈文虎(综述)[1] 毛伟敏(审校)[1] 

机构地区：[1]浙江省肿瘤医院检验科,杭州310022

出　　处：《肿瘤研究与临床》2009年第3期212-215,共4页Cancer Research and Clinic

摘　　要：肿瘤是一类细胞周期性疾病，将细胞周期调控因子导入肿瘤细胞可代替或补偿缺陷的基因以抑制肿瘤的异常增生或逆转基因型。p21^cip1是一种重要的细胞周期负调控蛋白，它参与细胞的生长、分化、衰老及死亡过程，同时又与肿瘤发生密切相关。就p21在肿瘤发生、发展中的作用及在肿瘤生物治疗中的主要策略作一综述。Cancer is frequently considered to be a disease of cell cycle. Recently, it is reported that the transfer of functional cell cycle regulators into cancer cells via vectors has the potential to intervene tumorigenesis development. This therapeutic strategy might allow cancer cells to regain missing or dysfunctional gene expression due to inhibiting aberrant proliferation or restoring phenotypes defects. As an important negative effecter of cell cycle progression,p21^cip1 not only plays central roles in cell proliferation, differentiation, senescence and apoptosis, but also associates with tumor regression. In this review, we will mainly focus on discussing some recent progress in novel strategies for cancer biological therapy, related with the functions of p21^cip1 in cell proliferation and apoptosis during tumorigenesis.

关 键 词：p21^cip1基因 肿瘤 治疗 

分 类 号：R737.902[医药卫生—肿瘤] R730.54[医药卫生—临床医学]