大肠腺瘤及其癌变的临床病理分析  

Clinical Pathological Factors of Colorectal Adenoma with Dysplasia and Cancerization

作　　者：刘惠民[1] 王蕾[1] 吴文新[2] 

机构地区：[1]河北工程大学医学院病理系,河北邯郸056002 [2]河北医科大学第二医院病理科

出　　处：《肿瘤防治研究》2009年第3期232-234,共3页Cancer Research on Prevention and Treatment

基　　金：河北省自然科学基金资助项目(C2006000911);河北省邯郸市科技局资助项目(072317064-2)

摘　　要：目的探讨大肠腺瘤及腺瘤癌变与临床病理特征的关系。方法回顾性分析大肠腺瘤及癌变病例与腺瘤大小、解剖部位、外形、病理类型的关系。结果776例大肠腺瘤患者发生癌变者为42例,癌变率为5.4%,绒毛状腺瘤癌变率最高,管状腺瘤癌变率较低;直肠腺瘤癌变率均高于右半结肠(P<0.05);大肠腺瘤癌变率随着腺瘤的增大而升高,并且广基形腺瘤比长蒂形腺瘤更易癌变。大肠腺瘤的癌变率随异型增生程度的增高而增高(P<0.05)。结论大肠腺瘤癌变与腺瘤大小、解剖部位、外形、病理类型及腺瘤异型增生程度等因素有关。Objective To study the relationship between colorectal adenoma with dysplasia and cancerization and clinico pathological characteristics. Methods The relationships were retrospectively analyzed between colorectal adenoma with dysplasia and cancerization and the tumor size, location, appearance, pathological type of colorectal adenoma. Results In all cases, carcinomatous incidence was 5.4% （42 cases）. The rate of malignant villous adenoma was high and malignant tubular adenoma was low. The incidence of malignant adenoma was significantly higher in rectum adenoma than that in the right colon adenoma （P〈0. 05）. The rate of colorectal adenoma with dysplasia and cancerization was increased with the size increasing. The incidence of cancerization was higher in flat adenorna than that in stemmed adenoma. Carcinomatous rate of colorectal adenoma was augmented as the degree of dysplasia increased（P〈0. 05）. Conclusion Many factors, such as the size, location, appearance, pathological type and the degree of dysplasia of colorectal adenoma were related with colorectal cancerization.

关 键 词：大肠腺瘤 腺瘤癌变 病理 

分 类 号：R735.34[医药卫生—肿瘤]