宫颈癌筛查系统及液基细胞学检测在宫颈病变筛查中的对比研究  

Comparing study of cervical cancer screening system and liquid-based cytology test in the screening of cervical lesions

作　　者：吕斯迹[1] 黄莉霞[1] 赵鑫[1] 薛雪[1] 童晓文[1] 吴乾渝[1] 

机构地区：[1]同济大学附属东方医院妇产科,上海200120

出　　处：《现代妇产科进展》2009年第2期90-93,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨宫颈癌筛查系统(TruScreen)与液基细胞学检测(liquid-based cytologytest,LCT)在宫颈病变诊断中的临床意义。方法:对487例患者行TruScreen、LCT检查,以阴道镜下病理学检查为金标准。比较两种方法的敏感度、特异度及假阴性率。结果:TruScreen、LCT阳性结果分别为229例和42例,病理学检查阳性结果为30例。Tru-Screen、LCT及TruScreen联合LCT检测的敏感度分别为73.3%、46.7%和90%,特异度分别为54.7%、93.9%和50.5%,假阴性率分别为26.7%、53.3%和10%。TruScreen及Tr-uScreen联合LCT检查敏感度高于LCT,差异有统计学意义(P<0.05),TruScreen与Tru-Screen联合LCT检查的敏感度无统计学差异(P>0.05)。结论:本研究中,TruScreen的效果评价高于LCT。在我国,TruScreen作为一种新的宫颈病变筛查技术可能会达到较好的筛查效果。Objective：To study the clinical value of cancer screening system （TruScreen） and liquid-based cytology test（LCT） in the diagnosis of cervical lesions. Methods ：487 cases of patients were screened by TruScreen and LCT based on the pathology result as a golden standard. To compare the sensitivity, specificity and fake negative rate of the two methods. Results：The postitive result cases of TruScreen and LCT were 229 and 42 ,the postitive result cases of pathlology were 30. The sensitivity of TruScreen, LCT and TruScreen combined with LCT were 54.7%, 93.9% and 50.5% ,the specificity were 54.7% ,93.9% and 50.5% ,the fake negative rates were 26.7% ,53.3% and 10% respectively. The difference of sensitivity between TruScreen ,TruScreen combined with LCT was significant （ P 〈 0.05 ）. And the difference of sensitivity between Tru-Screen and TruScreen combined with LCT was not significant （P 〉 0.05 ）. Conclusions： The value of TruScreen in dignosisis of cervical lesions is better than LCT in this research. As a new cervical lesion screening technology,TruScreen may be more effective in China.

关 键 词：宫颈癌筛查系统 液基细胞学检测 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]