他汀类药物对急性缺血性脑卒中患者外周血内皮祖细胞的影响  

Effect of Statin on Circulating Endothelial Progenitor Cells in Patients with Acute Ischemic Stroke

作　　者：陈雅玲[1] 董强[1] 

机构地区：[1]复旦大学附属华山医院神经内科,200040

出　　处：《中国临床神经科学》2009年第2期128-133,共6页Chinese Journal of Clinical Neurosciences

基　　金：上海市科委科研资助课题(编号:074119603)

摘　　要：目的:观察他汀类药物对急性缺血性脑卒中(AIS)患者外周血内皮祖细胞(EPC)数量及迁移能力的影响。方法: 15例发病1周内的AIS患者,给予阿托伐他汀20 mg·d^(-1),治疗4周,用药前及用药后每周分别检测外周血EPC数量及迁移能力;9名健康对照者于入组前及第2、4周随访。结果:阿托伐他汀治疗第2周开始EPC数量逐渐增多,且第3和第4周增多较为显著(P<0.05);EPC的迁移能力在治疗第2和第3周显著提高(P<0.05),而第4周则有下降的趋势。EPC数量及迁移能力的变化与低密度脂蛋白的下降无显著相关性。结论:他汀类药物可能提高AIS患者外周血EPC的数量及迁移能力。Aim： To study the impact of statin therapy on circulating endothelial progenitor cells （EPC） in patients with acute ischemic stroke （IS）. Methods： Fifteen patients with acute IS were treated with 20 mg.d^-1 of atorvastatin within 1 week after symptom onset. Before and weekly after the initiation of statin treatment, peripheral blood was drawn for detection of EPC counts and migration. In heathy control group（n=9）, EPC kinetics was investigated before and biweekly after recruited. Results： The circulating EPC counts gradually increased 2 weeks after statin treatment, and even increased significantly in the 3rd and 4th week（P〈0.05）; atorvastatin therapy significantly augmented the migration of EPC in the 2nd and 3rd week（P〈0.05）, which showed a decreasing trend in the 4th week. Neither of the change of EPC counts and migration manifested a correlation with low-density lipoprotein （LDL） lowering. Conclusion： Statin therapy may augment the counts and migration of EPC in acute IS patients.

关 键 词：急性缺血性脑卒中 他汀类药物 内皮祖细胞 

分 类 号：R743.3[医药卫生—神经病学与精神病学]