药物成瘾的蛋白质组学研究  

PROTEOMIC STUDY OF DRUG ADDICTION

作　　者：周晚玲[1] 朱永平[1] 

机构地区：[1]浙江大学医学院毒理研究室,杭州310058

出　　处：《生物物理学报》2009年第1期9-14,共6页Acta Biophysica Sinica

基　　金：国家重点基础研究发展计划(973计划)项目(2003CB515402);浙江省科技计划重点项目(2005C23G2010166);卫生部科学研究基金(WKJ2007-2-007)~~

摘　　要：药物成瘾涉及脑内多种蛋白含量、结构及功能的复杂改变,主要涉及代谢酶类、细胞骨架蛋白、分子伴侣、细胞内信号途径相关蛋白、突触功能相关蛋白和氧化还原相关蛋白等类型。蛋白质组学能对生理与病理状态下的体液、组织或细胞中基因组编码的所有蛋白质组分进行高通量的综合分析,针对筛选出的有意义"候选"蛋白(candidate protein)进行深入验证研究,不仅可能从蛋白质水平上阐明成瘾的神经生物学作用机制,还有助于建立诊断标准,发现抗成瘾药物治疗的潜在靶点。Drug addiction involved in the complex change of different kinds of brain protein content, structure and function, many of which were classified into metabolism, cytoskeletal proteins, chaperones, cell signaling pathway-related protein, synaptic function related protein and redox-related protein. Proteomics has the predominant potentiality to obtain high-throughout proteome mapping from sap, tissue or cell in the physiological and pathological states. By choosing the meaningful ＂candidate protein＂ for further study, which is benefit to reveal the role of addiction neurobiology mechanisms, establish the diagnostic criteria and eventually find potential treatment target.

关 键 词：精神活性物质 成瘾 蛋白质组学 

分 类 号：R-05[医药卫生] R349.2