Ghrelin fluctuation, what determines its production？  

作　　者：Xuefeng Yin Yin Li Geyang Xu Wenjiao An Weizhen Zhang 

机构地区：[1]Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China [2]Departrnent of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109-0346, USA

出　　处：《Acta Biochimica et Biophysica Sinica》2009年第3期188-197,共10页生物化学与生物物理学报（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China （30890043, 30740096, 30871194 and 30700376）, and the ＇985＇ Program at Peking University （985-2-097-121）.

摘　　要：Ghrelin, a 28 amino acid gut brain peptide, acts as an endogenous ligand for its receptor, the growth hormone secretagogue receptor, to exercise a variety of functions ranging from stimulation of growth hormone secretion, regulation of appetite and energy metabolism, and cell protection to modulation of inflammation. This review summarizes the advance in the regulation of ghrelin expression and secretion. We introduce the structure of ghrelin promoter, the processing and modification of ghrelin precursor, and the regulation mechanism in these processes. Then we discuss factors found to be important in the regulation of ghrelin production, including nutrients, hormones, and autonomic nervous system. Finally, we outline the alteration in the level of ghrelin in certain physiological and pathological status.Ghrelin, a 28 amino acid gut brain peptide, acts as an endogenous ligand for its receptor, the growth hormone secretagogue receptor, to exercise a variety of functions ranging from stimulation of growth hormone secretion, regulation of appetite and energy metabolism, and cell protection to modulation of inflammation. This review summarizes the advance in the regulation of ghrelin expression and secretion. We introduce the structure of ghrelin promoter, the processing and modification of ghrelin precursor, and the regulation mechanism in these processes. Then we discuss factors found to be important in the regulation of ghrelin production, including nutrients, hormones, and autonomic nervous system. Finally, we outline the alteration in the level of ghrelin in certain physiological and pathological status.

关 键 词：GHRELIN regulation DIET SECRETION BIOSYNTHESIS 

分 类 号：Q946.885.1[生物学—植物学] Q575.11