转肽酶(sortase)在口腔微生物中的研究进展  

Research progress on sortase in oral microorganism

作　　者：米媛[1] 于丹妮[1] 

机构地区：[1]天津医科大学第二医院口腔科,天津300211

出　　处：《牙体牙髓牙周病学杂志》2009年第3期167-170,共4页Chinese Journal of Conservative Dentistry

摘　　要：表面蛋白在G+细菌的致病性中起着重要作用。转肽酶(sortase)因为介导表面蛋白附着到细胞壁上,而被日益关注。它对病原菌致病的重要性,可能有助于新的治疗方法的实施。该文就转肽酶的性质及其在口腔细菌中的作用作一综述。Surface proteins of Gram - positive pathogens play various key roles in pathogenicity. A major mechanism for the surface display of these proteins is sortase - mediated covalent attachment to the cell wall. The importance of sortase in the virulence of several pathogens is now becoming apparent, and this finding may be exploited for the implementation of new therapeutic strategy. This review focuses on the character of sortases and the role that these enzymes play in oral bacterial pathogenesis.

关 键 词：转肽酶sortase 表面蛋白 口腔微生物 

分 类 号：R780.2[医药卫生—口腔医学]