妊高征孕妇胎盘组织中IGF-1、HIF-1α的表达变化及意义  

Expression and significance of IGF-1 and HIF-1α in placenta tissue of hypertensive disorder complicating pregnancy patients

作　　者：金丽[1] 陈芹[1] 李方英[1] 鲁晨[1] 张文敏[1] 班开斌[1] 

机构地区：[1]滕州市中心人民医院,山东滕州277500

出　　处：《山东医药》2009年第6期7-9,共3页Shandong Medical Journal

摘　　要：目的观察妊高征孕妇胎盘组织中胰岛素样生长因子(IGF)-1及缺氧诱导因子(HIF)-1α的表达变化,并探讨其在妊高征发病中的作用。方法采用免疫组化SP法检测70例妊高征患者(观察组)及70例正常妊娠妇女(对照组)胎盘组织中的IGF-1及HIF-1α。结果胎盘组织中IGF-1阳性率观察组为48.6%(34/70),对照组为82.8%(58/70),两组比较P<0.01;HIF-1α阳性率观察组为77.1%(54/70),对照组为38.5%(27/70),两组比较,P<0.01;观察组患者胎盘组织中IGF-1与HIF-1α的表达呈负相关(r=-0.265,P<0.01)。结论妊高征孕妇胎盘组织中IGF-1表达降低,HIF-1α表达上升。二者与妊高征发病及病情发展有关。Objective To investigate the expression and significance of insulin-like growthfaetor-1 （ IGF-1 ） and hypoxia-inducible factor-1 alpha （HIF-1α） in placenta tissue of hypertensive disorder complicating pregnancy patients. Method The level of IGF-1 and HIF-1α in placenta in 70 patients with hypertensive disorder complicating pregnancy（observation group） and 70 normal pregnant （control group）were detected by immunohistolngy. Result The placenta IGF-1 positive expression rate in observation group was 48.6% （34/70） and 82.8% （58/70） in control group,P 〈 0.01. The placenta HIF-1α positive expression rate in observation group was 77.1% （54/70） and 38.5% （27/70） in control group,P 〈0.01. The level of IGF-1 and HIF-1α in observation group showed obviously inverse correlation（r = -0. 265 ,P 〈 0.01 ）. Conclusion The expression of IGF-1 in placenta tissue of hypertensive disorder complicating pregnancy patients increases, and HIF-1α decreases. Both of them are related the occurrence and development of hypertensive disorder complicating pregnancy.

关 键 词：妊娠期高血压综合征 胎盘 胰岛素样生长因子-1 缺氧诱导因子-1Α 

分 类 号：R737.33[医药卫生—肿瘤]