米非司酮对子宫肌瘤血管生成素-2作用的研究  

Effects of mifepristone on the expression of Ang-2 in uterine leiomyoma

作　　者：高英芳[1] 梁丽华[1] 刘素巧[2] 宋慧英[1] 孙聪欣[1] 龚静[1] 

机构地区：[1]河北省石家庄市第四医院,050011 [2]河北省石家庄市第二医院

出　　处：《河北医药》2009年第5期527-529,共3页Hebei Medical Journal

摘　　要：目的探讨米非司酮对子宫肌瘤的作用机制及对肌瘤组织血管生成素-2(Ang-2)的作用和影响。方法50例因子宫肌瘤行手术切除子宫患者,随机分为对照组与服药组各25例,服药组术前口服米非司酮3个月,每日12.5mg,B型超声监测子宫及肌瘤体积变化;对照组术前3个月不服任何药物。术后用免疫组化SP法测定2组子宫肌瘤组织Ang-2的表达,并用图像分析法测定二者的表达强度。结果B型超声显示服药后子宫及子宫最大肌瘤的平均体积比用药前分别缩小了27.90%,和43.06%,差异均有统计学意义(P<0.01);服药后免疫组化结果显示,服药组子宫肌瘤组织Ang-2表达阳性率48%;对照组Ang-2表达阳性率72%,差异有统计学意义(P<0.05)。结论米非司酮可通过抑制子宫平滑肌瘤中Ang-2的表达,缩小子宫肌瘤及子宫体积。Objective To investigate the action mechanism of mifepristone on uterine leiomyoma and effects of mifepristone on the expression of angiopoietin-2 （Ang-2） in hysteromyoma. Methods 50 patients who received hysterectomy because of hysterumyoma were divided into two groups, 25 patients in each group. The 25 patients in mifepristone group underwent surgical operation after pretreatment with mifepristone 12.5 mg/d for 3 months and the volume of uterus and leiomyoma was detected by B ultrasound ; the other 25 patients in control group underwent surgical operation without any pretreatment. After surgery, the expression of Ang-2 in leiomyoma of the two groups was detected by immunohistochemistry SP method and the expression intensity was measured by image analysis method. Results The result of B ultrasound showed that after administration the average volumes of uterine and the biggest leiomyoma were reduced by 27.9% and 43% respectively, these differences were all significant （ P 〈 0. 01 ）. The result of immunohistochemistry showed that after administration the positive expression rates of Ang-2 in mifepristone group and control group were 48 % , 72 % respectively. There was a significant difference between the two groups （ P 〈 0. 05）. Conclusion Mifepristone can inhibit the expression of Ang-2 in leiomyoma to reduce the volumes of uterine and leiomyoma.

关 键 词：米非司酮 子宫平滑肌瘤 血管生成素-2 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]