磁共振成像动态增强扫描在前列腺癌诊断中的价值  

Dynamic contrast enhanced MRI and PSA for diagnosis and differentiation of prostate cancer

作　　者：张鹏[1] 

机构地区：[1]山东省新泰市人民医院,271200

出　　处：《实用医技杂志》2009年第3期168-170,共3页Journal of Practical Medical Techniques

摘　　要：目的通过绘制时间信号强度曲线,探讨磁共振成像(MRI)快速序列动态增强在前列腺癌诊断及鉴别诊断中的价值,并观察前列腺特异抗原(PSA)在诊断前列腺癌与增生中的作用。方法对5例无泌尿系症状患者、经病理证实的前列腺癌13例患者及前列腺增生36例患者行MR平扫、动态增强及延迟扫描,测量并计算病灶和正常组织的相对信号强度值,并绘制正常周围带、前列腺癌与增生三者的时间信号强度曲线。同时观察比较癌与增生患者的PSA值。结果正常周围带轻度强化,并缓慢上升至晚期达峰值;36例前列腺增生患者早期明显强化并逐渐上升至中晚期达峰值后缓慢下降;13例前列腺癌患者9例早期明显强化,并快速下降,4例T2WI像上弥漫性病灶呈现中晚期强化。前列腺癌尤其是晚期癌患者的PSA值明显高于增生患者。结论正常周围带、前列腺癌及前列腺增生的动态强化方式明显不同,结合PSA可对前列腺癌的诊断与鉴别诊断起到积极作用。Objective To assess the role of dynamic contrast enhanced MRI and PSA for diagnosis and differentiation of prostate cancer. Methods Five patients of normal prostate, 36 patients of benign prostatic hyperplasia and 13 patients with biopsy-proven prostate cancer underwent MR imaging. Dynamic MR with gadolinium-diethylenetriaminepen-taaceticacid bolus enhancement was performed , followed by postcontrast T1-weighed imaging. To measure and calculate the singal intensive value in dynamic MRI, and to draw the time-signal intensity curve of normal peripheral zone and prostate cancer and benign hyperplasia, and to compare the PSA levels of prostate cancer and benign hyperplasia. Results In dynamic MRI, the normal peripheral zone were enhanced mildly and slowly, the Peak value was located on late phase. 36 patients of benign prostatic hyperplasia were enhanced obviously in early and graduately, the Peak value was located on midlle and late phase. 9 of 13 prostate cancer enhanced obviously in early and wash out in late phase, the Peak value was located on early phase. Specialy, the PSA levels of the advanced prostate cancer were more high than the benign hyperplasia＇s. Conclusion In dynamic MRI, the enhancement of normal peripheral zone and prostate cancer and benign hyperplasia were differrent signifinfly, Dynamic MRI and PSA was useful in diagnosis and differentiation of prostate cancer.

关 键 词：磁共振成像 动态增强扫描 时间信号强度曲线 正常周围带 前列腺癌 良性前列腺增生 

分 类 号：R737.25[医药卫生—肿瘤] R734.2[医药卫生—临床医学]