度他雄胺的合成  

Synthesis of Dutasteride

作　　者：何明华[1] 廖清江[2] 

机构地区：[1]广东医学院药学院药物化学教研室,广东东莞523808 [2]中国药科大学药物化学教研室,江苏南京210009

出　　处：《化工时刊》2009年第3期44-46,共3页Chemical Industry Times

摘　　要：以孕烯酮酸为起始原料,经过氧化开环、环合、还原、氧化,酰基胺化共5步制得目标产物,总收率为31.2%。探索了同条件对各个合成中间体的产率的影响,找出合适的反应条件,使之更适于工业生产。The target compound was synthesized from androst - 3 - one - 4 -ene - 17 - carboxylic acid via five steps, including oxidative ring opening, cyclization, reduction, oxidization and finally acylahon. The overall yield was 31.2%. The effects of different reaction conditions on the yield of product in each step were investigated and the opti- mum reaction conditions were established for suitable for industrial production.

关 键 词：度他雄胺 孕烯酮酸 5-Α还原酶抑制剂 IBX 

分 类 号：TQ463.2[化学工程—制药化工]