微卫星不稳定性、hMLH1及FHIT基因与胃癌关系的研究进展  

Research progress on relationship among microsatellite instability,HMLH1, FHIT gene and gastric carcinoma

作　　者：冯艳玲[1] 李冬霞[2] 张红旗[3] 

机构地区：[1]上海市(复旦大学附属)公共卫生临床中心病理科,上海201508 [2]河南省新乡医学院机能实验室,河南新乡453003 [3]复旦大学上海医学院解剖组胚系,上海200032

出　　处：《中国现代医学杂志》2009年第5期700-704,共5页China Journal of Modern Medicine

摘　　要：目前国内外学者对胃癌的病因、遗传易感和癌变机制进行了较广泛的研究,但发病的确切分子机制仍未完全阐明。hMLH1基因是一个错配修复基因,其功能异常后,导致细胞错配修复功能缺陷,产生遗传不稳定性,表现为微卫星不稳定性(micro satellite instability,MSI)增加及继发原癌基因和抑癌基因的突变。FHIT基因作为一个新的抑癌基因,其失活与许多上皮性恶性肿瘤的发生密切相关。该文仅对MSI、hMLH1及FHIT基因与胃癌关系的研究现状作一综述。Though many researcher both aboard and home have made some investigation in the cause of a disease, affectability and cancerization mechanism of gastric carcinoma, their exact molecule mechanism is not completely elucidated, hMLH1 gene is a mismatch repair gene, It＇s disfunction can result in the functional defect of mismatch repair and develop genetic instability, that is the increase of Microsatellite Instability and the mutation of sec- ond proto-oncogene and anti-oncogene. FHIT gene is new anti-oncogene, it＇s deactivation have close relations with the development of many endothelial malignant tumor. The article will review the relationship among microsatellite instability, hMLH1, FHITgene and gastric eareinoma.

关 键 词：胃癌 HMLH1 FHIT 微卫星不稳定性 

分 类 号：R735.2[医药卫生—肿瘤]