肺癌患者血清血管内皮生长因子水平与预后的相关性研究  

Correlation of serum levels of vascular endothelial growth factor and prognosis in patients with lung cancer

作　　者：姜正华[1] 桑慧颖[1] 吕元文[1] 朱慕云[1] 王正东[1] 许文景[1] 

机构地区：[1]扬州大学临床医学院(江苏省苏北人民医院)呼吸内科,江苏扬州225001

出　　处：《中国现代医学杂志》2009年第5期775-779,共5页China Journal of Modern Medicine

基　　金：江苏省扬州市社会发展计划(No:YZ2005Z019)

摘　　要：目的探讨肺癌患者血清血管内皮生长因子(VEGF)水平及与肺癌临床患者病理特征关系及与预后的相关性。方法采用酶联免疫吸附法(ELISA)对60例肺癌患者及20例健康人的血清VEGF进行测定。结果肺癌患者血清VEGF水平显著高于健康对照组(P<0.01),肺癌患者血清VEGF水平与患者的年龄、性别、病理类型、肿瘤大小、TNM分期、有无远处转移等临床病理特征之间无明显关系。肺癌患者血清VEGF水平与其生存期之间呈显著的负相关(r=-0.38,P<0.01)。结论肺癌患者存在血清VEGF水平增高,血清VEGF水平与患者的预后密切相关,血清VEGF是评估肺癌患者预后的重要指标。[Objective] To study the relationship between the serum levels of vascular endothelial growth factor on pathophysiological characteristics and prognosis in patients with lung cancer. [Methods] The serum levels of vascular endothelial growth factor were detected in sixty patients with lung cancer and twenty normal controls by ELISA method. [Results] The serum levels of vascular endothelial growth factor in patients with lung cancer were significantly higher than those of normal controls. The serum levels of vascular endothelial growth factor in patients with lung cancer were not related to age, sex, histological classification, the size of the primary tumors, P-TNM stages, distant metastasis. The serum levels of vascular endothelial growth factor in patients with lung cancer were negatively correlated to survival （r =-0.38, P 〈13.01）. [Conclusions] Elevation of serum levels of vascular endothelial growth factor exists in patients with lung cancer, the serum levels of vascular endothelial growth factor were significantly correlation to the prognosis in patients with lung cancer, the serum levels of vascular endothelial growth factor were important marker of prognosis of patients with lung cancer.

关 键 词：肺癌 血管内皮生长因子 预后 

分 类 号：R734.2[医药卫生—肿瘤]