复方苦参注射液持续滴注联合肝动脉化疗栓塞治疗中晚期原发性肝癌20例疗效观察  

Therapeutic Effect of Continuous Intusion of Compound Kushen Injection Combined with Hepatic Arterial Chemoembolization for Advanced Liver Cancer:An Observation of 20 Cases

作　　者：邓力[1] 黎壮伟[1] 吴薏婷[1] 卢秋红[1] 陈力舟[1] 吴锦燕[1] 吴晓燕[1] 陈庆强[1] 

机构地区：[1]广州市中医院肿瘤二区,广东广州510130

出　　处：《新中医》2009年第4期28-29,共2页New Chinese Medicine

摘　　要：目的:探讨复方苦参注射液持续滴注联合肝动脉化疗栓塞(TACE)治疗中晚期原发性肝癌的临床疗效。方法:选择不宜手术的中晚期肝癌患者40例,随机分为治疗组和对照组各20例,均采用TACE治疗。治疗组在术后第2天行外周中心静脉置管(PICC),连接化疗泵,每天持续24小时静脉滴注复方苦参注射液。结果:2组均无显著缓解病例,治疗组无变化例数较对照组高,但差异无显著性意义(P>0.05)。在疼痛缓解疗效方面,治疗组比对照组具有较高的缓解率,差异有显著性意义(P<0.05)。在腹胀缓解疗效方面,治疗组较对照组具有较高的缓解率,差异有显著性意义(P<0.05)。治疗组Karnofsky(KPS)评分显著提高,与治疗前比较,差异有非常显著性意义(P<0.01),对照组也有提高,但与治疗前比较,差异无显著性意义(P>0.05)。2组治疗后比较,差异有显著性意义(P<0.05)。2组在血常规、肝肾功能等方面未见明显毒副反应。结论:复方苦参注射液静脉持续滴注联合TCAE治疗中晚期原发性肝癌疗效显著,能改善患者症状和生活质量,为中西医结合治疗肝癌提供了一条新的途径。Objective:To observe the therapeutic effect of continuous infusion of Compound Kushen Injection(CKI)combined with hepatic arterial chemoembolisation for advanced liver cancer. Methods:Forty advanced liver cancer patients who lost the chance of operation were equally randomised into the control group and the treatment group.The two groups received trans-arterial chemo-embolisation(TACE),and the treatment group received all-day continuous infusion CKI on the second day after TACE additionally.Results:None was completed relieved or partially relieved in the two groups.The number of patients staying unchanged was higher in the treatment group than that in the control group,but the difference was insignificant(P>0.05).The pain relieving rate was higher in the treatment group than that in the control group,the difference being significant(P<0.05).So did the abdominal distention relieving rate.The Karnofsky score was increased in the treatment group(P<0.01 compared with that before treatment),and it was also increased in the control group,but the difference was insignificant(P>0.05 compared with that before treatment).The difference of Kamofky score in the two groups after treatment was significant (P<0.05).No obvious toxic and reverse reaction was found in the two groups.Conclusion: Continuous infusion of CKI combined with hepatic arterial chemoembolization is effective for advanced liver cancer through relieving symptoms and improving quality of life,which will supply a new way of Chinese medicine and western medicine for liver cancer.

关 键 词：肝癌 中西医结合疗法 肝动脉化疗栓塞 复方苦参注射液 

分 类 号：R735.7[医药卫生—肿瘤]