C-erbB-2、p53的联合检测对大肠癌预后的多因素分析  

Evaluation of C-erbB-2 and p53 in multivariable analysis of colorectal cancer

作　　者：李波[1] 邹扬[1] 胡志军[1] 姚尧[1] 张频[1] 汪昱[1] 郑起[1] 

机构地区：[1]上海交通大学附属第六人民医院,上海200233

出　　处：《山东医药》2009年第12期18-20,共3页Shandong Medical Journal

摘　　要：目的研究大肠癌患者肿瘤组织C-erbB-2、p53的表达与临床病理学类型及预后的联系。方法应用免疫组织化学SP法检测有完整随访资料的126例大肠癌术后肿瘤组织的p53,C-erbB-2蛋白的表达,应用Kap-lan-Meier法Cox比例风险模型分析检测结果同预后关系。结果在126例大肠癌患者中,组织中p53阳性表达65例(51.6%),C-erbB-2阳性表达60例(47.6%),p53与C-erbB-2阳性表达均与区域淋巴结转移显著相关。p53与C-erbB-2阴性患者的生存率要高于阳性患者。多因素COX回归分析显示,p53、Dukes分期、年龄能反映大肠癌的预后情况,C-erbB-2、p53和Dukes分期是大肠癌的独立预后指标。结论检测C-erbB-2和p53可能有助于筛选出具有高复发及转移倾向的大肠癌患者。Objective To explore the protein expression of C-erbB-2, p53 （two oncogenes） in colorectal cancer （CRC） tissues and relation to the elinico-pathological parameters and prognosis. Methods Expression of C-erbB-2, p53 in paraffin-fixed tissue sections collected from 126 patients of CRC with integral follow up data were detected by SP immunohistoehemical staining, Kaplan-Meier method and multivariable Cox proportional hazard model were used to analyze the relationship between expressions of these 2 proteins and patient prognosis. Results The positive rate of C-erbB-2 and lo53 was 47.6% and 51.6% respectively, and they were related to the lymph node metastasis. Survival rate of the group with negative expression of C-erbB-2 was higher than that of the postive group. Expression of lO53, lymph node metastasis, Dukes classification and ages were four important and independent prognostic factors for CRC. Conclusion Detection of p53 and C-erbB-2 may be helpful for screening the highly recurrent case with risk of metastasis.

关 键 词：大肠肿瘤 预后 蛋白质P53 基因 ERBB-2 

分 类 号：R735.3[医药卫生—肿瘤]