TIP30在胃癌组织中的表达及其对胃癌血管生成的影响  

Expression of TIP30 and its correlation with angiogenesis in gastric cancers

作　　者：徐忠凯[1] 郑春宁[2] 孙少川[2] 姜永胜[2] 赵东[2] 

机构地区：[1]山东大学医学院,山东济南250012 [2]山东大学附属济南市中心医院普外科,山东济南250013

出　　处：《中国现代普通外科进展》2009年第2期110-113,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:研究Tat作用蛋白30(Tat-interactive protein 30,TIP30)基因在胃癌组织中的表达及其对胃癌血管生成的影响。方法:运用免疫组织化学方法检测52例胃癌组织及47例癌旁正常组织中TIP30蛋白的表达水平,同时检测CD34标记的微血管密度(microvessel density,MVD)。结果:TIP30在胃癌和癌旁正常组织中的阳性率分别为53.8%和85.1%,两者相比较差异有统计学意义(χ2=11.22,P﹤0.01),TIP30表达水平与患者年龄、性别、病理分化程度及肿瘤大小无关,与有无淋巴结转移及TNM分期有关。胃癌组织和癌旁正常组织中MVD值分别为27.37±2.68和21.87±4.11,两者比较差异有统计学意义(t=7.95,P<0.01),胃癌组织中TIP30表达阳性者较阴性者MVD值显著降低(t=-3.18,P=0.003)。结论:TIP30在胃癌组织中表达降低,其可能通过抑制胃癌血管生成影响胃癌的发生发展。Objective： To investigate the expression of TIP30 in gastric cancer tissues and analyze its impact with angiogenesis. Methods： The expression of TIP30 and CD34-labeled microvessel density CMVD） were measured by immunohistochemical staining in 52 cases of gastric carcinomas and 47cases of Para-cancer tissues. Results： the positive rate of TIP30 was 53.8% and 85. 1 % in cancerous tissues and para-cancer tissues, there were significant differences between them （χ^2= 11 .22, P〈0.01 ）. The expression of TIP30 in gastric cancer was observed to correlate with lymph node metastasis and TNM stage, but not related with age, sex, celt differentiation and size of carcinoma. The MVD were 27.37 ± 2.68 and 21.87 ± 4.11 in cancerous tissues and para-cancer tissues.There were obvious differences （ t= 7.95,P〈0.01 ）.The MVD in TIP30-positive tissues was much lower than in negative tissues （t=-3.18,P=0.003 ）.Conclusions： the expression level of TIP30 decreases obviously in gastric caicinoma. The effect of TIP30 gene for tumor genesis and growth may be partially completed through depression of vessel formation.

关 键 词：胃肿瘤 新生血管化 病理性 Tat作用 蛋白30基因 

分 类 号：R735.2[医药卫生—肿瘤]