乳腺癌TGF-β_1和BRCA2表达及意义  

Expression and Signification of TGF-β_1 and BRCA2 in Breast Cancinoma

作　　者：李军川[1] 竺红宇[2] 陈廷煊[1] 代桂华[1] 赵会传[1] 任红兵[1] 邹兰英[1] 郭琼[1] 

机构地区：[1]长江大学附属第一医院暨湖北省荆州市第一人民医院病理科,湖北荆州434000 [2]长江大学附属第一医院暨湖北省荆州市第一人民医院呼吸内科,湖北荆州434000

出　　处：《中国误诊学杂志》2009年第11期2527-2529,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨乳腺癌TGF-β1和BRCA2表达意义。方法:应用免疫组化S-P法检测乳腺癌、癌旁组织及正常乳腺组织中TGF-β1和BRCA2的表达水平。结果:TGF-β1、BRCA2在c-erbB-2阳性组与阴性组比较有统计学意义(P<0.05),在癌组织分别与癌旁组织和乳腺组织的表达比较有统计学意义(P<0.01)。结论:TGF-β1及BRCA2在乳腺癌中过表达,与c-erbB-2表达有一定协同性,联合三者的检测,可同时成为预测乳腺癌预后的指标。Objective：To explore the relationship between the expression of TGF-beta1,BRCA2 and its biological behavior in breast carcinoma. Methods ：Immunohistocbemistry of S-P method was used to detect the expression of TGF- beta1 and BRCA2 in 67 cases mammary glandular tissues,latero-cancer tissue and cancer tissue. Results ：The significant difference was observed in the expression of TGF-beta1 and BRCA2 in breast cancer tissues,latero-cancer and mammary glandular tissues（P〈0.01）. The protein exprssion of TGF-beta1 and BRCA2 was direct correlation with c-erbB-2（P〈0.05）. Conclusion：Abnormal expressig TGF-beta1 and BRCA2 in breast carcinoma indicate what are relation of occurring and development, it is useful to forecast development of breast carcinoma by combining to examine.

关 键 词：转化生长因子β/代谢 BRCA2蛋白质/代谢 乳腺肿瘤/代谢 人类 

分 类 号：R737.9[医药卫生—肿瘤]