外周血血小板计数与食管癌临床病理相关性研究  

Platelet count of peripheral blood is associated with invasion and metastasis of esophageal carcinoma

作　　者：余新春[1] 吴善水[1] 陆晓青 盛李明[3] 胡雅国[1] 赵健[1] 李娟梅[1] 邵海燕[1] 

机构地区：[1]浙江省衢州市人民医院病理科,浙江衢州324000 [2]衢州市妇保院病理科,浙江衢州324000 [3]浙江大学附属第二医院,浙江杭州310009

出　　处：《浙江大学学报（医学版）》2009年第2期170-173,共4页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省科技厅科研基金项目(2008C33014);浙江省医药卫生科研基金资助项目(2007A203);衢州市科技计划项目(20071060)

摘　　要：目的:研究外周血血小板与食管癌的关系。方法:比较415例食管癌患者及325例对照人群血小板水平,并分析血小板水平与食管癌患者临床病理参数之间的关系。结果:食管癌患者外周血血小板水平(286±88)×109/L显著高于正常人群(204±114)×109/L;食管癌患者血小板增多的比例为23.6%,高于对照组(P<0.05)。食管癌患者血小板与肿瘤浸润深度、淋巴结转移有关(P<0.05)。结论:血小板升高可能与食管癌的发展有关。Objective： To analyze the association between the platelet count of peripheral blood and clincopathologic parameters of esophageal carcinoma. Methods： Platelets of peripheral blood were measured in 415 cases of esophageal carcinoma and 325 healthy subjects as control. The correlation of platelet counts and clinicopathological features of cancer was analyzed. Results： Platelet count in patients with esophageal carcinomas （286±88）×10^9/L was significantly higher than that in the control subjects [（204±114）×10^9/L,P〈0.05]. Increased platelet counts （〉 3005×10^9/L） was significantly associated with tumor infiltration and lymph node metastasis in patients with esophageal cancer （P〈0. 05）. Conclusion： Platelet count of peripheral blood might be associated with the development and progression of esophageal cancer.

关 键 词：食管肿瘤/病理学 血小板增多/病因学 肿瘤侵润 淋巴转移 食管癌 

分 类 号：R735.1[医药卫生—肿瘤]