CAG治疗急性巨核细胞白血病变为首发的慢性粒细胞白血病(首例报道及文献复习)  

CAG Regimen for Chronic Myeloid Leukemia in Megakaryocytic Blast Crisis (the First Case Report and Literature Review)

作　　者：谢静[1] 何广胜[1] 吴德沛[1] 孙爱宁[1] 金正明[1] 仇惠英[1] 苗瞄[1] 薛胜利[1] 赵晔[1] 王秀丽[1] 

机构地区：[1]苏州大学附属第一医院血液科江苏省血液研究所卫生部止血与血栓重点实验室,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2008年第6期1007-1009,共3页Suzhou University Journal of Medical Science

基　　金：江苏省青年科技创新人才基金资助项目(BK2004424);江苏省135重点学科开放基金资助项目(135XY0416);江苏省医学领军人才资助项目(LJ200626);苏州大学附属第一医院优秀青年骨干基金资助项目(2004YQG05)

摘　　要：目的探讨慢性粒细胞白血病急性巨核细胞白血病变后的表现和治疗方法。方法报道1例以急性巨核细胞白血病为首发表现的慢性粒细胞白血病(CML),先后予以CAG方案和伊马替尼治疗。结果该患者获得血液学及分子生物学缓解,且耐受良好。结论极少数CML患者以急性巨核细胞白血病为首发表现,CAG方案、伊马替尼有较好疗效。Objective To describe the clinical manifestations of chronic myeloid leukemia in megakaryocytic blast crisis and discuss the therapy for it.Methods One case of megakaryocytic blast crisis was reported as the first presentation of chronic myeloid leukemia and the therapy of CAG and i-matinib.Results The patient achieved the completed hematological and molecular remission.Con-clusion Very rare cases of megakaryocytic crisis have been described as the first presentation of chronic myeloid leukemia,which has a good response to CAG and imatinib.

关 键 词：急性巨核细胞白血病变 慢性粒细胞白血病 CAG方案 伊马替尼 

分 类 号：R733.7[医药卫生—肿瘤]