胰腺癌组织中Syk的表达及意义  

Expression and significance of Syk in pancreatic adenocarcinoma

作　　者：王琦[1] 王长亮[2] 崔凯[2] 张波[2] 周武元[2] 于文胜[2] 仲伟霞[2] 李胜[2] 

机构地区：[1]北京友谊医院,北京100050 [2]山东省肿瘤防治研究院

出　　处：《山东医药》2008年第39期21-23,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30600603);山东省自然科学基金资助项目(Y2007F06);山东省科技发展计划基金资助项目(20070GG20002022)

摘　　要：目的探讨胰腺癌组织中脾酪氨酸激酶(Syk)的表达情况及意义。方法用免疫组化法和RT-PCR检测40例胰腺癌组织、9例慢性胰腺炎、8例正常胰腺组织中的Syk蛋白及其mRNA,形态计量学图象分析法测定微淋巴管密度(MLVD)。结果Syk蛋白在胰腺癌、慢性胰腺炎和正常胰腺组织中阳性率分别为27.5%、77.8%和100%;Syk蛋白与胰腺癌TNM分期、分化程度和淋巴结转移有关(P<0.05)。Syk mRNA在胰腺癌中呈低表达(P<0.01)。胰腺癌组织中微淋巴管密度(MLVD)在TNM分期III^IV期组显著高于I^II期组(P<0.05),淋巴结转移阳性组显著高于阴性组(P<0.01)。Syk蛋白阴性表达者的MLVD显著高于阳性组(P<0.01)。结论Syk在胰腺癌中表达减低或缺失,与胰腺癌的发展显著相关。Objective To study the expression and significance of Syk in pancreatic adenocarcinoma （PAC）. Syk proteins in PAC,eaneerous peripheral tissue and the normal pancreatic tissues were assayed by staining and RT-PCR. Results The positive rates of Syk protein in PAC,cancerous peripheral tissues and normal pancreatic tissues were 27.5% and 77.8% and 100% respectively. The Sky mRNA was lower expression in PAC. The MLVD was higher in III- IV stages than I - II stages of PAC （ P 〈 0.01 ） and was higher in negative group than that in positive group of Syk protein （ P 〈 0.01 ）. Conclusions The expression of Syk in PAC is significantly lower and it is related to development of pancreatic cancer of PAC.

关 键 词：脾酪氨酸激酶 淋巴管生成 胰腺肿瘤 

分 类 号：R735.9[医药卫生—肿瘤]