雷公藤多苷对肝脏的双重作用及其思考  

Dual Function of Tripterygium Glycosides Acting on Liver and Its Consideration

作　　者：禄保平[1] 吕沛宛[1] 杨晓慧[1] 

机构地区：[1]河南中医学院肝病研究所,河南郑州450008

出　　处：《医学与哲学（B）》2009年第3期70-71,共2页Medicine & Philosophy(B)

基　　金：河南省高校科技创新人才支持计划项目;项目编号:2009HASTIT009;河南省高等学校青年骨干教师资助计划项目;项目编号:教高[2007]335号;河南省科技攻关计划项目;项目编号:0624410086

摘　　要：文献研究表明,雷公藤多苷既可治疗肝脏疾病,又能引起肝脏毒性。本文对其双重作用从不同角度进行了分析,认为药物均存在治疗作用和毒副作用的双重效应,且与用药剂量、时间密切相关,并从严控剂量时间、加强监测、重视"治未病"、改进剂型等方面提出了应对措施。Literature study indicates that tripterygium glycosides could not only treat liver diseases, but also lead to hepatotoxicity. This article makes an analysis of the dual function of therapeutic and toxicity in different terms, and holds that all drugs exit the dual effect. Moreover, it is closely related to the dosage and time. Finally, measures of controlling dosage and time, improving monitoring, giving emphasis to prevention before being ill and improving on dosage form are put forward.

关 键 词：雷公藤多苷 肝脏 治疗作用 毒副作用 预防 

分 类 号：R969.1[医药卫生—药理学]