单核苷酸多态性、环境因素与肝细胞肝癌遗传易感性的关系  

Relationship of single nucleotide polymorphism, environmental factors and the hereditary susceptibility of hepatocellular carcinoma

作　　者：纪龙[1] 余红平[1] 

机构地区：[1]广西医科大学公共卫生学院,南宁530021

出　　处：《卫生研究》2009年第2期233-237,共5页Journal of Hygiene Research

基　　金：国家自然科学基金资助项目(No.30660162);广西自然科学基金资助项目(No.桂科攻0592007-21);广西研究生教育创新计划资助项目(No.2008105981004M189);广西大型仪器协作网测试补助(No.529-2007-108)

摘　　要：肝细胞肝癌(HCC)的发生和演进是一个多基因、多因素的复杂过程,是遗传与环境因素相互作用的结果。单核苷酸多态性(SNP)作为第三代遗传标记,充分反映了个体间的遗传差异,决定了个体对疾病的易感性,正成为肝癌遗传易感性研究的重要工具。Resuhing by the interaction between the hereditary factor and the environmental factor, the occurrence and development of hepatocellular carcinoma（HCC） is a complicated course with multi-genes and multi-factors. As the third genetic marker, the single nucleotide polymorphism reflects the hereditary difference among individuals, decides the susceptibility to disease and becomes an important tool to study the hereditary susceptibility of HCC.

关 键 词：单核苷酸多态性 环境因素 肝细胞肝癌 遗传易感性 肝肿瘤 

分 类 号：R735.7[医药卫生—肿瘤] R730.1[医药卫生—临床医学]