小檗胺及喜得镇对实验性脑缺血保护作用的研究  

The protective effect of berbamine and dihydroe gotoxine on experimental cerebral ischemia

作　　者：周虹[1,2] 王玲[1,2] 郝晓敏[1,2] 高云瑞 李文汉[1,2] 

机构地区：[1]哈尔滨医科大学药理学教研室 [2]中国药理学会

出　　处：《中国药理学通报》1998年第2期165-166,共2页Chinese Pharmacological Bulletin

基　　金：卫生部"八五"攻关项目

摘　　要：目的研究小檗胺及喜得镇对实验性脑缺血的保护作用。方法用结扎同侧大脑中动脉及颈总动脉的方法，制备大鼠局灶性脑缺血模型。结果小檗胺及喜得镇可缩小大鼠脑缺血２４ｈ后皮层梗塞面积、减少脑组织含水量、减少丙二醛（ＭＤＡ）的产生、增强超氧化物歧化酶（ＳＯＤ）的活性。且两药半量配伍用明显优于各药全量单用。结论小檗胺及喜得镇对实验性脑缺血具有保护作用。AIM It was studied that the protective effect of berbamine and dihydroe gotoxine on experimental cerebral ischemia. METHODS The acute local cerebral ischemia in rats was induced by ligating the middle cerebral artery and common carotid artery in the same time. RESULTS Berbamine and dihydroe gotoxine could obviously decrease the ischemic area and the water content of brain tissue, reduce production of MDA, and enhance activity of SOD after 24 hours of ischemia. The combination effect of the two drugs in half doses of each much greater than that of total dose of each separately. CONCLUSION Berbamine and dihydroe gotoxine possess protective effect on experimental cerebral ischemia.

关 键 词：小檗胺 喜得镇 脑缺血 脑水肿 保护作用 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]