雌激素、孕激素及其受体在甲状腺乳头状癌中的表达  

Expression of Estrogen,Progesterone and Their Receptors in Papillary Thyroid Carcinoma

作　　者：薛兆石[1] 刘金彪[1] 王新征[1] 杨俊川[1] 邓淼[1] 

机构地区：[1]河南科技大学第一附属医院,河南洛阳471003

出　　处：《河南科技大学学报（医学版）》2009年第1期9-10,共2页Journal of Henan University of Science & Technology:Medical Science

摘　　要：目的探讨雌激素(estrogen,E)、孕激素(progesterone,P)及其受体ER(estrogen receptor,ER)、PR (progesterone receptor,PR)在甲状腺乳头状癌中的表达及意义。方法应用化学发光法测定36例甲状腺乳头状癌患者血中的雌、孕激素水平;应用免疫组化SP法检测其癌组织中ER及PR的表达。结果36例甲状腺乳头状癌患者中雌、孕激素(77.8%和69.4%)均高于正常对照组,ER及PR阳性表达率分别为72.2%和69.4%。与对照组相比,雌、孕激素水平及ER、PR表达均有明显差异。结论多数甲状腺乳头状癌患者雌、孕激素水平升高, ER及PR高表达。Objective To study the significance and expression of estrogen （estrogen, E）, progesterone （ progesterone, P） and their reeeptors ER （ estrogen receptor, ER） PR （ progesterone receptor, PR） in papillary thyroid carcinoma（PTC）. Methods Estrogen and progesterone were determined by chemiluminescence in blood of 36 patients with PTC, ER and PR in the specimens were assessed by immunohistoehemieal assay. Results In 36 cases, estrogen in 77.8% cases and progesterone in 69.4% were more than normal level, The positive rate of ER and PR was 72.2% and 69.4%. The level of estrogen and progesterone was significantly different between control group and PTC, as well as the expression of ER and PR. Conclusion The level of estrogen and progesterone in many patients with PTC is more than norm. The positive rate of ER and PR is detected significantly. PTC is a hormone-dependent tumor.

关 键 词：甲状腺乳头状癌 雌激素 孕激素 雌激素受体 孕激素受体 免疫组化 

分 类 号：R736.1[医药卫生—肿瘤]