AgNOR技术及CT扫描联合诊断肺癌纵隔淋巴结转移的可行性研究  

Role of AgNOR Study Combined with CT Scan in the Diagnosis of Mediastinal Lymph Node Metastasis of Lung Cancer

作　　者：刘勇[1,2] 魏江平[1,2] 路名芝[1,2] 李启明[1,2] 王夷黎[1,2] 陈大贤[1,2] 

机构地区：[1]江西省人民医院病理科 [2]江西省人民医院放射科

出　　处：《中国肿瘤临床》1998年第7期484-486,共3页Chinese Journal of Clinical Oncology

摘　　要：探讨ＡｇＮＯＲ技术及ＣＴ扫描联合诊断肺癌纵隔淋巴结转移的可行性。应用ＡｇＮＯＲ技术和ＣＴ扫描对３８例肺癌纵隔淋巴结转移情况进行分析。伴淋巴结转移肺癌的ＡｇＮＯＲ／核均数显著高于无淋巴结转移肺癌（Ｐ＜０．０５）。ＣＴ扫描淋巴结短径≥８ｍｍ的１０例肺癌中淋巴结转移７例，此７例肺癌细胞的ＡｇＮＯＲ／核均数为８．９７±０．７２，且ＡｇＮＯＲ颗粒均表现为聚集型。提示以肺癌细胞核内ＡｇＮＯＲ颗粒为聚集型，Ａｇ－ＮＯＲ／核均数≥８，ＣＴ扫描淋巴结短径≥８ｍｍ作为标准诊断肺癌纵隔淋巴结转移有较高的特异性及敏感性。To investigate the role of AgNOR count of biopsied specimens combined with CT in the diagnosis of mediastinal lymph node metastasis of lung cancer. By using AgNOR count on bronscopic biopsy cells combined with CT scan of chest mediastinal lymph node metastasis in 38 cases of lung cancer were evaluated. The mean counted number of AgNOR biopsied specimens from patients with lung cancer with lymph node metastasis was higher than that　without (P<0.05). Lymph node metastases were found in 7 out of 10 cases of lung　cancer in whom the shortest diameter of the enlarged lymph node was ≥ 8mm. In addition　the mean number of AgNOR was 8.97±72. Meanwhile, the AgNOR granules tended to clump in aggregations. It is suggested in cases where the AgNOR granules presented as aggregative type, the mean count being 8 or more,the short　axis of 8mm strongly suggestive of lung cancer with mediastinal lymph node　metastases with a high specificity and sensitivity. AgNOR technique combined with　CT scanning unveils good prospects for the diagnosis of mediastinal lymph node　metastasis in patient with lung cancer.

关 键 词：肺肿瘤 纵隔淋巴结 肿瘤转移 AGNOR染色 CT 

分 类 号：R734.204[医药卫生—肿瘤]