原发性肝癌患者红细胞免疫功能与超氧化物歧化酶关系的探讨  

Relationship between Red Cell Immune Function and Serum Superoxide Dismutase in Primary Liver Cancer

作　　者：张登学[1] 张翠萍[1] 张琪[1] 姜月萍 

机构地区：[1]青岛医学院附属医院

出　　处：《中国肿瘤临床》1998年第7期516-517,共2页Chinese Journal of Clinical Oncology

基　　金：青岛医学院科研基金

摘　　要：观察３２例原发性肝癌（ＰＨＣ）患者红细胞Ｃ３ｂ受体花环率（Ｅ－Ｃ３ｂＲＲ）、红细胞免疫复合物花环率（Ｅ－ＩＣＲ）及血清超氧化物歧化酶（ＳＯＤ）含量，并与正常人比较。结果表明：ＰＨＣ病人的红细胞免疫功能低下，血清ＳＯＤ含量增高，且两者呈负相关改变。提示：ＰＨＣ患者红细胞免疫功能的降低与机体的脂质过氧化损伤存在相互间关系，其功能的紊乱可能是ＰＨＣ发病过程中的一个重要因素。如何提高ＰＨＣ患者红细胞免疫调控能力。Thirtytwo cases of primary liver cancer were studied by measuring EC3 bRR, EICR and serum contents of TSOD, MnSOD, Cu,ZnSOD to observe the relationship between the red cell immune function and SOD .The results showed　 that the serum content of SOD in patients was higher (P<0.01) and that the red　 cell immune function in patients was lower than those　in the normal healthy subjects (P<0.05). Therefore, the red cell immune function was in negative　 correlationship with SOD in patients with primary liver cancer. It is suggested that　 the reduced red cell immune function is associated with the impairment of lipid　 peroxidization of the patients and that it may be one of the key etiological factors of this disease.

关 键 词：肝肿瘤 原发性 红细胞免疫功能 SOD 

分 类 号：R735.7[医药卫生—肿瘤]