低分子量肝素诱导重症急性胰腺炎大鼠胰腺腺泡细胞凋亡的实验研究  

Experimental study of low molecular weight heparin inducing acinar cell apoptosis in severe acute pancreatitis

作　　者：范钦桥[1] 陈书伟[1] 杨根辉[1] 刘博[1] 曹文声[1] 于毅[1] 吕新生[2] 范立侨[3] 

机构地区：[1]湖南省郴州市第一人民医院肝胆外科,湖南郴州423001 [2]中南大学湘雅医院普通外科 [3]河北医科大学第四医院外三科

出　　处：《中国医师杂志》2009年第3期342-344,共3页Journal of Chinese Physician

摘　　要：目的探讨低分子肝素（LMWH）治疗重症急性胰腺炎的机理。方法建立假手术组（S组）、重症急性胰腺炎组（SAP组）和LMWH治疗组（H组），比较各组死亡率、血清淀粉酶、IL-6、腺泡细胞凋亡指数和胰腺组织NF-κB活性。结果H组死亡率、血清淀粉酶和IL-6明显低于SAP组（P〈0．01）。H组腺泡细胞凋亡指数明显高于SAP组（P〈0．01）。H组胰腺组织NF-κB活性明显低于SAP组。结论LMWH可能通过抑制NF-κB的活性，从而诱导了胰腺腺泡细胞凋亡，减轻胰腺炎症程度。Objective To explore the mechanism of LMWH therapy for SAP. Methods 48 wistar rats were random divided into 3 groups, sham group （S group） , severe acute pancreatitis group （SAP group） and LMWH therapy group （H group）. Serum amylase, IL-6, aeinar cell apoptosis and the activity of NF-κB were detected and compared： Results The expression of amylase and IL-6 in SAP group was significantly higher than that in H group （ P 〈0. 01 ）. The apoptosis index of aeinar cell in SAP group was significantly lower than that in H group （ P 〈 0. 01 ）, while the activity of NF-κB in SAP group was stronger than that in H group. Conclusions LMWH therapy may amelio- rate SAP by inducing aeinar cell apoptosis through suppressing the activity of NF-κB.

关 键 词：肝素 低分子量/药理学 胰腺炎/病理生理学 胰腺/细胞学 细胞凋亡 

分 类 号：R576[医药卫生—消化系统]