β-环糊精包合肉豆蔻挥发油的工艺研究  

Preparation of β-Cyclodextrin Inclusion Compound of Volatile Oil in Semen Myristicae

作　　者：杨红艳[1] 王国炳[1] 林三清[1] 

机构地区：[1]湛江师范学院化学科学与技术学院,广东湛江524048

出　　处：《中国药业》2009年第7期30-31,共2页China Pharmaceuticals

基　　金：湛江师范学院青年资助项目;项目编号:QL0704

摘　　要：目的研究β-环糊精(β-CD)包合肉豆蔻挥发油的最佳工艺。方法以挥发油包合率、包合物收率为指标,对研磨法、超声法和饱和水溶液法进行比较试验。采用正交设计法优选饱和水溶液法对肉豆蔻挥发油β-CD包合的最佳工艺条件。结果优选出的最佳包合工艺为肉豆蔻挥发油:β-CD(1:6)、包合温度60℃、包合时间1h。结论确定了肉豆蔻挥发油的β-CD包合最佳工艺,为包合物制剂学研究和质量控制提供依据。Objective To optimize the processing conditions for the inclusion of Semen Myristicae oil by β- cyelodextrin（β- CD）. Methods Selecting the inclusion rate and the yield of inclusion compounds as the control indexes, to make a comparative test with the methods of trituration method, ultrasound method and saturarated water solution method. The orthogonal test was used to select the best inclusion prepa- ration condition. Results The optimized preparation technology for inclusion compound was volatile oil： β- CD（1：6）, with the inclusion temperature of 60℃ and the inclusion time of l h. Conclusion The optimum β- CD inclusion technology for volatile oil from Semen Myristicae is established and provides the basis for the study of inclusion preparation and quality control.

关 键 词：肉豆蔻挥发油 Β-环糊精 包合工艺 

分 类 号：TQ461[化学工程—制药化工]