缓释氟尿嘧啶辅助治疗腹膜假性粘液瘤的安全性研究和短期随访  

A Retrospective Study of Implanting 5-Fluorouracil Sustained-release to Prolong Remission Period of Pseudomyxoma Peritonei Syndrome

作　　者：李沛雨[1] 刘娜[1] 李荣[1] 卫勃[1] 

机构地区：[1]解放军总医院普通外科,北京100853

出　　处：《中国医药导刊》2009年第2期255-256,258,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨缓释氟尿嘧啶在腹膜假性粘液瘤(PP)辅助治疗中的作用.研究其应用安全性。方法:伴有腹胀、肠梗阻的PP病人26例,手术保证其肿瘤残留量小于10%,其中9例术中放置缓释氟尿嘧啶,9例行单纯化疗,8例无处理,所有病人术后均复发,仅统计第一次复发的症状缓解期。结果:联合化疗组(术中缓释氟尿嘧啶加术后化疗)、单纯化疗组、无处理组病人症状缓解期分别为(16.67±7.86)月,(12.44±5.81)月,(8.75±2.18)月.组间有统计学差异。结论:应用缓释氟尿嘧啶对延缓PP复发有一定作用,可在一定程度上提高病人生存期和生活质量,且临床应用安全。Objective：To evaluate the clinical effect and security of implanting 5 - Fluorouracil （5 - Fu ） Sustained - release in prolonging remission period after operation of pseudomyxoma peritonei syndrome. Methods： 26 Patients with digestive tract obstruction or severe abdominal distension were treated by different methods, 9 patients received treaunent combining 5 - fu sustained - release during operation with chemotherapy postoperation. 9 patients received only chemotherapy pnstoperation. 8 patients received only chemotherapy postoperation, all cases recurfenced and the remission stage of the symptoms was analyzed. Results： The remission stage of the symptoms in combined treatment group, simple chemotherapy group, no treatment group is （ 16. 67 ± 7. 86 ） months, （ 12.44 ± 5.81 ） months, （ 8.75± 2. 18 ） months respectively. Conclusions： 5 -Ftuorouracil （5 -Fu） Sustained -release is safety to use during operation and effective to prolong the remission period of patient,s with pseudomyxoma peritonei syndrome.

关 键 词：腹膜假性粘液瘤 肿瘤复发 局部/预防和控制 缓释氟尿嘛啶 

分 类 号：R735.5[医药卫生—肿瘤]