中国南北方汉族急性淋巴细胞白血病患者HLA基因分型特征  

Polymorphism of HLA-A,B and DRB1 Alleles in Chinese Han Patients with Acute Lymphoblastic Leukemia

作　　者：程曦[1] 林创松[1] 程良红[1] 金士正[1] 邹红岩[1] 高素青[1] 

机构地区：[1]中华骨髓库深圳HLA分型实验室,深圳市血液中心研究所,广东深圳518035

出　　处：《现代检验医学杂志》2009年第2期9-12,共4页Journal of Modern Laboratory Medicine

基　　金：中华骨髓库合作项目、深圳市科技计划项目（200603202）.

摘　　要：目的研究中国南北方汉族急性淋巴细胞白血病（ALL）患者人群中人类白细胞抗原（HLA）-A，B，DRB1等位基因的分布特征.方法根据11个南方省区556名南方汉族和18个北方省区644名北方汉族ALL患者的HLA—A，B，DRB1表型数据，采用最大似然性方法分别计算两个群体的HLA—A，B，DRB1等位基因和单倍型频率并采用卡方检验方法比较其分布特征.结果南北方汉族ALL患者群体中，A＊02，A＊11，A＊24，A＊33，B＊13，B＊46，B＊51，B＊60，B＊62，DRB1＊04，DRB1＊08，DRB1＊09，DRB1＊11，DRB1＊12，DRB1＊14和DRB1＊15均比较常见，另外B＊58，B＊62和B＊75仅在南方群体中较高，而A＊30，B＊35，B＊61和DRB1＊07则仅常见于北方患者，7个A，12个B和5个DRB1等位基因的分布存在显著性差异.结论中国南北方汉族ALL患者人群HLA—A，B，DRB1等位基因的分布有其自身特征，此研究数据可作为ALL患者群体的HLA相关研究和应用的参考数据.Objective To study the polymorphism of HLA-A, B,DRBlalleles in Chinese Han patients with ALL. Methods The frequencies of HLA-A, B, DRB1 alleles were estimated by Expectation-Maximization method based on the genotypes of 556 southern Chinese Han with ALL patients from 11 south province and 644 northern Chinese Han from 18 north province in China and then compared by chi-square test. Results A ＊ 02,A ＊ 11 ,A ＊ 24,A ＊ 33,B ＊ 13,B ＊ 46 ,B ＊ 51 ,B 60,B ＊ 62,DRB1 ＊ 04,DRB1 ＊ 08,DRB1 ＊ 09,DRB1 ＊ 11,DRB1 ＊ 12,DRB1 ＊ 14 and DRB1 ＊ 15 were frequent alleles in both southern and northern Chinese Han with ALL patients groups,B ＊＊ 58,B ＊ 62 and B ＊ 75 frequent only in southern group,whereas,A ＊ 30,B ＊ 35,B ＊＊ 61 and DRB1 ＊ 07 only in northern. The distribution of seven A, twelve B and five DRB1 alleles were different with statistically significant. Conclusion The distribution of HLA-A,B and DRB1 alleles are different with statistically significant in southern and northern Chinese Han ALL groups,and the frequencies of HLA-A,B and DRB1 alleles could be serve as some researches and applications correlated with ALL.

关 键 词：急性淋巴细胞白血病 人类白细胞抗原(HLA) 等位基因 频率 

分 类 号：R733.71[医药卫生—肿瘤] Q781[医药卫生—临床医学]